『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 単独著作 (徳島大学内の単一の研究グループ(研究室等)内の研究 (単著も含む)) [継承]
学究種別 (推奨): 博士課程学生による研究報告 [継承]
組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
著者 (必須): 1. (英) Dang Van Huy (日) ダン ヴァン ホイ (読) だん ゔぁん ふぃー
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学籍番号 (推奨): **** [ユーザ]
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2.坂井 隆志
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3. (英) Pham Anh Tuan (日) ファン アン トゥアン (読) ふぁん あん とん
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学籍番号 (推奨): **** [ユーザ]
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4. (英) Tran Hong Diem (日) チャン ホン ディエム (読)
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5.頼田 和子
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6.宍戸 裕二 ([徳島大学.先端酵素学研究所.次世代酵素学研究領域])
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7.福井 清 ([徳島大学])
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題名 (必須): (英) Nucling, a Novel Apoptosis-associated Protein, Controls Mammary Gland Involution by Regulating NF-B and STAT3  (日)    [継承]
副題 (任意):
要約 (任意): (英) Postpartum mammary gland involution is the physiological process by which the lactating gland returns to its pre-pregnant state. In rodent models, the microenvironment of mammary gland involution is sufficient to induce enhanced tumor cell growth, local invasion, and metastasis. Therefore, a deeper understanding of the physiological regulation of involution may provide in-depth information on breast cancer therapy. We herein identified Nucling as an important regulator of involution of the mammary gland. A knock-out mouse model was generated and revealed that postpartum involution were impaired in mice lacking Nucling. Involution is normally associated with an increase in the activation of NF-B and STAT3, which is required for the organized regulation of involution, and was observed in WT glands, but not in the absence of Nucling. Furthermore, the loss of Nucling led to the suppression of Calpain-1, IL-6, and C/EBP factors, which are known to be essential for normal involution. The number of M2 macrophages, which are crucial for epithelial cell death and adipocyte repopulation after weaning, was also reduced in Nucling-KO glands. Taken together, the results of the present study demonstrated that Nucling played an important role in mammary gland involution by regulating NF-B and STAT3 signaling pathways.  (日)    [継承]
キーワード (推奨):
発行所 (推奨): The American Society for Biochemistry and Molecular Biology [継承]
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 1083-351X
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J. Biol. Chem.
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 290 [継承]
(必須): 40 [継承]
(必須): 24626 24635 [継承]
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年月日 (必須): 西暦 2015年 10月 2日 (平成 27年 10月 2日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.M115.673848    (→Scopusで検索) [継承]
PMID (任意): 26269594    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1074/jbc.M115.673848  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC4591840 [Available on 10/02/16]  (日)    [継承]
4.(英) KeywordList.Keyword: NF-B  (日)    [継承]
5.(英) KeywordList.Keyword: STAT3  (日)    [継承]
6.(英) KeywordList.Keyword: apoptosis  (日)    [継承]
7.(英) KeywordList.Keyword: macrophage  (日)    [継承]
8.(英) KeywordList.Keyword: mammary gland  (日)    [継承]
9.(英) KeywordList.Keyword: mammary gland involution  (日)    [継承]
10.(英) KeywordList.Keyword: nucling  (日)    [継承]

標準的な表示

和文冊子 ● Huy Van Dang, Takashi Sakai, Tuan Anh Pham, Diem Hong Tran, Kazuko YORITA, Yuji Shishido and Kiyoshi Fukui : Nucling, a Novel Apoptosis-associated Protein, Controls Mammary Gland Involution by Regulating NF-B and STAT3, The Journal of Biological Chemistry, Vol.290, No.40, 24626-24635, 2015.
欧文冊子 ● Huy Van Dang, Takashi Sakai, Tuan Anh Pham, Diem Hong Tran, Kazuko YORITA, Yuji Shishido and Kiyoshi Fukui : Nucling, a Novel Apoptosis-associated Protein, Controls Mammary Gland Involution by Regulating NF-B and STAT3, The Journal of Biological Chemistry, Vol.290, No.40, 24626-24635, 2015.

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