『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Tanaka H (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Yang G-X (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Iwakoshi N (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Knechtle J. S (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Kawata K (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6.常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Leung P (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Coppel L. R (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Ansari A. A (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Joh T (日) (読)
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学籍番号 (推奨):
[継承]
11. (英) Bowlus C (日) (読)
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学籍番号 (推奨):
[継承]
12. (英) Gershwin E. M (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) While there have been significant advances in our understanding of the autoimmune responses and the molecular nature of the target autoantigens in primary biliary cirrhosis (PBC), unfortunately these data have yet to be translated into new therapeutic agents. We have taken advantage of a unique murine model of autoimmune cholangitis in which mice expressing a dominant negative form of transforming growth factor receptor II (dnTGFRII), under the control of the CD4 promoter, develop an intense autoimmune cholangitis associated with serological features similar to human PBC. CD40-CD40 ligand (CD40L) is a major receptor-ligand pair that provides key signals between cells of the adaptive immune system, prompting us to determine the therapeutic potential of treating autoimmune cholangitis with anti-CD40L antibody (anti-CD40L; MR-1). Four-week-old dnTGFRII mice were injected intraperitoneally with either anti-CD40L or control immunoglobulin (Ig)G at days 0, 2, 4 and 7 and then weekly until 12 or 24 weeks of age and monitored for the progress of serological and histological features of PBC, including rigorous definition of liver cellular infiltrates and cytokine production. Administration of anti-CD40L reduced liver inflammation significantly to 12 weeks of age. In addition, anti-CD40L initially lowered the levels of anti-mitochondrial autoantibodies (AMA), but these reductions were not sustained. These data indicate that anti-CD40L delays autoimmune cholangitis, but the effect wanes over time. Further dissection of the mechanisms involved, and defining the events that lead to the reduction in therapeutic effectiveness will be critical to determining whether such efforts can be applied to PBC.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibodies, Monoclonal (日) (読) [継承]
3. (英) Antigens, CD4 (日) (読) [継承]
4. (英) Antigens, CD40 (日) (読) [継承]
5. (英) Autoantigens (日) (読) [継承]
6. (英) Autoimmune Diseases (日) (読) [継承]
7. (英) Autoimmunity (日) (読) [継承]
8. (英) CD40 Ligand (日) (読) [継承]
9. (英) Cholangitis (日) (読) [継承]
10. (英) Cytokines (日) (読) [継承]
11. (英) Disease Models, Animal (日) (読) [継承]
12. (英) Disease Progression (日) (読) [継承]
13. (英) Genotype (日) (読) [継承]
14. (英) Liver (日) (読) [継承]
15. (英) Liver Cirrhosis, Biliary (日) (読) [継承]
16. (英) Mice (日) (読) [継承]
17. (英) Mice, Inbred C57BL (日) (読) [継承]
18. (英) Mitochondria (日) (読) [継承]
19. (英) Promoter Regions, Genetic (日) (読) [継承]
20. (英) Receptors, Transforming Growth Factor beta (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 1365-2249
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
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(必須): 174 [継承]
(必須): 3 [継承]
(必須): 364 371 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 12月 初日 (平成 25年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/cei.12193    (→Scopusで検索) [継承]
PMID (任意): 23981074    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1111/cei.12193  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) OtherID: PMC3826303  (日)    [継承]
5.(英) KeywordList.Keyword: anti-CD40 ligand antibody  (日)    [継承]
6.(英) KeywordList.Keyword: autoimmunity  (日)    [継承]
7.(英) KeywordList.Keyword: cholangitis  (日)    [継承]
8.(英) KeywordList.Keyword: primary biliary cirrhosis  (日)    [継承]

標準的な表示

和文冊子 ● H Tanaka, G-X Yang, N Iwakoshi, S J. Knechtle, K Kawata, Koichi Tsuneyama, P Leung, R L. Coppel, A A. Ansari, T Joh, C Bowlus and M E. Gershwin : Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis., Clinical and Experimental Immunology, Vol.174, No.3, 364-371, 2013.
欧文冊子 ● H Tanaka, G-X Yang, N Iwakoshi, S J. Knechtle, K Kawata, Koichi Tsuneyama, P Leung, R L. Coppel, A A. Ansari, T Joh, C Bowlus and M E. Gershwin : Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis., Clinical and Experimental Immunology, Vol.174, No.3, 364-371, 2013.

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