『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=304674EID:304674, Map:0, LastModified:2016年2月6日(土) 18:58:49, Operator:[常山 幸一], Avail:TRUE, Censor:0, Owner:[常山 幸一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Tanaka H (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Zhang W (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Yang G-X (日) (読)
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[継承]
4. (英) Ando Y (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Tomiyama T (日) (読)
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学籍番号 (推奨):
[継承]
6.常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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学籍番号 (推奨):
[継承]
7. (英) Leung P (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Coppel L. R (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Ansari A. A (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Lian X. Z (日) (読)
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学籍番号 (推奨):
[継承]
11. (英) Ridgway M. W (日) (読)
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学籍番号 (推奨):
[継承]
12. (英) Joh T (日) (読)
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学籍番号 (推奨):
[継承]
13. (英) Gershwin E. M (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Treatment of primary biliary cirrhosis (PBC) has lagged behind that of other autoimmune diseases. In this study we have addressed the potential utility of immunotherapy using regulatory T cells (Treg ) to treat murine autoimmune cholangitis. In particular, we have taken advantage of our ability to produce portal inflammation and bile duct cell loss by transfer of CD8(+) T cells from the dominant negative form of transforming growth factor beta receptor type II (dnTGF-RII) mice to recombination-activating gene (Rag)1(-/-) recipients. We then used this robust established adoptive transfer system and co-transferred CD8(+) T cells from dnTGF-RII mice with either C57BL/6 or dnTGF-RII forkhead box protein 3 (FoxP3(+) ) T cells. Recipient mice were monitored for histology, including portal inflammation and intralobular biliary cell damage, and also included a study of the phenotypical changes in recipient lymphoid populations and local and systemic cytokine production. Importantly, we report herein that adoptive transfer of Treg from C57BL/6 but not dnTGF-RII mice significantly reduced the pathology of autoimmune cholangitis, including decreased portal inflammation and bile duct damage as well as down-regulation of the secondary inflammatory response. Further, to define the mechanism of action that explains the differential ability of C57BL/6 Treg versus dnTGF-RII Treg on the ability to down-regulate autoimmune cholangitis, we noted significant differential expression of glycoprotein A repetitions predominant (GARP), CD73, CD101 and CD103 and a functionally significant increase in interleukin (IL)-10 in Treg from C57BL/6 compared to dnTGF-RII mice. Our data reflect the therapeutic potential of wild-type CD4(+) FoxP3(+) Treg in reducing the excessive T cell responses of autoimmune cholangitis, which has significance for the potential immunotherapy of PBC.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Autoimmune Diseases (日) (読) [継承]
3. (英) Cholangitis (日) (読) [継承]
4. (英) Cytokines (日) (読) [継承]
5. (英) Disease Models, Animal (日) (読) [継承]
6. (英) Forkhead Transcription Factors (日) (読) [継承]
7. (英) Immunophenotyping (日) (読) [継承]
8. (英) Immunotherapy, Adoptive (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Mice, Inbred C57BL (日) (読) [継承]
12. (英) Mice, Transgenic (日) (読) [継承]
13. (英) Phenotype (日) (読) [継承]
14. (英) Spleen (日) (読) [継承]
15. (英) T-Lymphocyte Subsets (日) (読) [継承]
16. (英) T-Lymphocytes, Regulatory (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 1365-2249
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 178 [継承]
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(必須): 253 261 [継承]
都市 (任意):
年月日 (必須): 西暦 2014年 11月 初日 (平成 26年 11月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/cei.12415    (→Scopusで検索) [継承]
PMID (任意): 25041369    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1111/cei.12415  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) OtherID: PMC4233375 [Available on 11/01/15]  (日)    [継承]
5.(英) KeywordList.Keyword: autoimmunity  (日)    [継承]
6.(英) KeywordList.Keyword: cholangitis  (日)    [継承]
7.(英) KeywordList.Keyword: colitis  (日)    [継承]
8.(英) KeywordList.Keyword: murine models  (日)    [継承]
9.(英) KeywordList.Keyword: primary biliary cirrhosis  (日)    [継承]

標準的な表示

和文冊子 ● H Tanaka, W Zhang, G-X Yang, Y Ando, T Tomiyama, Koichi Tsuneyama, P Leung, R L. Coppel, A A. Ansari, Z X. Lian, W M. Ridgway, T Joh and M E. Gershwin : Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells., Clinical and Experimental Immunology, Vol.178, No.2, 253-261, 2014.
欧文冊子 ● H Tanaka, W Zhang, G-X Yang, Y Ando, T Tomiyama, Koichi Tsuneyama, P Leung, R L. Coppel, A A. Ansari, Z X. Lian, W M. Ridgway, T Joh and M E. Gershwin : Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells., Clinical and Experimental Immunology, Vol.178, No.2, 253-261, 2014.

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