『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Tanaka H (日) (読)
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[継承]
2. (英) Yang G-X (日) (読)
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[継承]
3. (英) Tomiyama T (日) (読)
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[継承]
4.常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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学籍番号 (推奨):
[継承]
5. (英) Zhang W (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Leung S. C. P (日) (読)
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[継承]
7. (英) Coppel L. R (日) (読)
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[継承]
8. (英) Joh T (日) (読)
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[継承]
9. (英) Nadler G. S (日) (読)
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[継承]
10. (英) Ansari A. A (日) (読)
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学籍番号 (推奨):
[継承]
11. (英) Bowlus C (日) (読)
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[継承]
12. (英) Gershwin E. M (日) (読)
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[継承]
題名 (必須): (英) Immunological potential of cytotoxic T lymphocyte antigen 4 immunoglobulin in murine autoimmune cholangitis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Cytotoxic T lymphocyte antigen 4 (CTLA-4) immunoglobulin (Ig) is an important regulator of T cell activation and a fusion protein directed at CD80 and CD86; it blocks co-stimulatory signalling and T cell activation. We have taken advantage of a murine model of human primary biliary cirrhosis (PBC), mice expressing a transforming growth factor (TGF)- receptor II dominant negative (dnTGF-RII) transgene to address the potential therapeutic efficacy of CTLA-4 Ig. To mimic patients with PBC at different stages or duration of disease, we treated mice with either CTLA-4 Ig or control IgG three times weekly from 3 to 12 or 24 weeks of age, or from 12 to 24 weeks of age. CTLA-4 Ig treatment from 3 weeks of age significantly reduced liver inflammation to 12 weeks of age. Treatment initiated at 12 weeks of age also ameliorated the autoimmune cholangitis at 24 weeks of age. However, in mice treated at 3 weeks of age, suppression of liver inflammation was not sustained and colitis was aggravated when treatment was extended to 24 weeks of age. Our data indicate that, in dnTGF-RII mice, CTLA-4 Ig treatment has short-term beneficial effects on autoimmune cholangitis, but the effect varies according to duration of treatment and the time in which therapy was initiated. Further dissection of the events that lead to the reduction in therapeutic effectiveness of CTLA-4 Ig will be critical to determining whether such efforts can be applied to human PBC.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Autoantibodies (日) (読) [継承]
3. (英) Autoimmune Diseases (日) (読) [継承]
4. (英) Autoimmunity (日) (読) [継承]
5. (英) CTLA-4 Antigen (日) (読) [継承]
6. (英) Cholangitis (日) (読) [継承]
7. (英) Disease Models, Animal (日) (読) [継承]
8. (英) Immunoglobulin G (日) (読) [継承]
9. (英) Immunoglobulins (日) (読) [継承]
10. (英) Liver (日) (読) [継承]
11. (英) Lymphocyte Activation (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Transgenic (日) (読) [継承]
14. (英) Mitochondria (日) (読) [継承]
15. (英) Protein-Serine-Threonine Kinases (日) (読) [継承]
16. (英) Receptors, Transforming Growth Factor beta (日) (読) [継承]
17. (英) T-Lymphocyte Subsets (日) (読) [継承]
18. (英) Time Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 1365-2249
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 371 382 [継承]
都市 (任意):
年月日 (必須): 西暦 2015年 6月 初日 (平成 27年 6月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/cei.12581    (→Scopusで検索) [継承]
PMID (任意): 25581259    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1111/cei.12581  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC4449766 [Available on 06/01/16]  (日)    [継承]
4.(英) KeywordList.Keyword: autoimmunity  (日)    [継承]
5.(英) KeywordList.Keyword: cholangitis  (日)    [継承]
6.(英) KeywordList.Keyword: colitis  (日)    [継承]
7.(英) KeywordList.Keyword: murine models  (日)    [継承]
8.(英) KeywordList.Keyword: primary biliary cirrhosis  (日)    [継承]

標準的な表示

和文冊子 ● H Tanaka, G-X Yang, T Tomiyama, Koichi Tsuneyama, W Zhang, P S. C. Leung, R L. Coppel, T Joh, S G. Nadler, A A. Ansari, C Bowlus and M E. Gershwin : Immunological potential of cytotoxic T lymphocyte antigen 4 immunoglobulin in murine autoimmune cholangitis., Clinical and Experimental Immunology, Vol.180, No.3, 371-382, 2015.
欧文冊子 ● H Tanaka, G-X Yang, T Tomiyama, Koichi Tsuneyama, W Zhang, P S. C. Leung, R L. Coppel, T Joh, S G. Nadler, A A. Ansari, C Bowlus and M E. Gershwin : Immunological potential of cytotoxic T lymphocyte antigen 4 immunoglobulin in murine autoimmune cholangitis., Clinical and Experimental Immunology, Vol.180, No.3, 371-382, 2015.

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