| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): | □ | 依頼
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| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○学究種別 (推奨): |
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| ○著者 (必須): | 1. | 川人 伸次 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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| 2. | (英) Katsutoshi Nakahata (日) (読)
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| 3. | (英) Toshiharu Azma (日) (読)
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| 4. | 黒田 泰弘
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| 5. | (英) David J Cook (日) (読)
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| 6. | (英) Hiroyuki Kinoshita (日) (読)
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| ○題名 (必須): | □ | (英) Protective effects of anesthetics on vascular function related to K+ channels (日)
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| ○要約 (任意): | □ | (英) K(+) channels play an essential role in the membrane potential of arterial smooth muscle, and also in regulating contractile tone. Especially, in vascular smooth muscle, the opening of adenosine triphosphate (ATP)-sensitive K(+) (KATP) channels leads to membrane hyperpolarization, resulting in muscle relaxation and vasodilation. This activation also plays a role in tissues during pathophysiologic events such as ischemia, hypoxia, and vasodilatory shock. In this review, we will describe the physiological and pathophysiological roles of vascular smooth muscle KATP channels in relation to the effects of anesthetics. Although accumulated evidence suggests that many anesthetics modify the above function of K(+) channels as a metabolic sensor, further studies are certainly needed to resolve certain issues, especially in clinical settings of anesthesia use. (日)
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| ○キーワード (推奨): | 1. | (英) anesthetics (日) (読)
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| 2. | (英) vascular function (日) (読)
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| 3. | (英) K+ channels (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Current Pharmaceutical Design (Bentham Science Publishers)
(pISSN: 1381-6128, eISSN: 1873-4286)
| ○ISSN (任意): | □ | 1873-4286
ISSN: 1381-6128
(pISSN: 1381-6128, eISSN: 1873-4286) Title: Current pharmaceutical designTitle(ISO): Curr Pharm DesPublisher: Bentham Science Publishers (NLM Catalog)
(Scopus)
(CrossRef)
(CrossRef)
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| ○巻 (必須): | □ | 20
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| ○号 (必須): | □ | 36
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| ○頁 (必須): | □ | 5727 5737
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2014年 2月 初日 (平成 26年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2174/1381612820666140204115647 (→Scopusで検索)
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| ○PMID (任意): | □ | 24502572 (→Scopusで検索)
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| ○WOS (任意): | □ | 000342006100007
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Review (日)
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