『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=304028EID:304028, Map:0, LastModified:2015年9月14日(月) 15:35:37, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[松井 尚子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.三ツ井 貴夫
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2. (英) Kuroda Yukiko (日) (読)
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3. (英) Ueono Shu-ichi (日) (読)
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4.松井 尚子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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5.梶 龍兒
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題名 (必須): (英) FK506 attenuates thymic output in patients with myasthenia gravis  (日)    [継承]
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要約 (任意): (英) Myasthenia gravis (MG) is an antibody-mediated, T-cell-dependent autoimmune disease. The symptoms are caused by high-affinity IgG against the muscle acetylcholine receptor (AChR) at the neuromuscular junction. The production of these antibodies in B-cells depends on AChR-specific CD4(+) T-cells and the thymus gland seems to play a significant role in the pathogenesis of MG. Altered thymic T-cell export seems to be associated with a pathological mechanism in myasthenia gravis. Tacrolimus (FK506) has recently been used to treat MG. We examined the effects of tacrolimus on thymic T-cell export in patients with MG. Sixteen patients with nonthymomatous and/or thymectomized MG were treated with oral administrations of tacrolimus. To assess the effect of tacrolimus on the thymic output, we assayed the levels of T-cell receptor excision circle (TREC), a molecular marker of thymus emigrants. T-cell receptor excision circle was not significantly different from those in age-matched controls before tacrolimus therapy, but they were partially decreased 4 months after tacrolimus therapy. T-cell receptor excision circle levels were significantly decreased in the thymomatous group (p < 0.05), but not in the nonthymomatous group. Tacrolimus treatment significantly attenuated TREC levels in cultured CD4(-)CD8(+) cells (p < 0.05), but total cell counts were not significantly changed. These results indicate that TREC levels may become a marker of the curative effect of tacrolimus therapy for thymomatous MG, and that tacrolimus suppresses not only activating T-lymphocytes, but also naïve T-cells.  (日)    [継承]
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誌名 (必須): Archives of Medical Science : AMS (Termedia)
(pISSN: 1896-9151, eISSN: 1734-1922)

ISSN (任意): 1734-1922
ISSN: 1734-1922 (pISSN: 1734-1922, eISSN: 1896-9151)
Title: Archives of medical science : AMS
Title(ISO): Arch Med Sci
Publisher: Termedia Publishing House Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 6 [継承]
(必須): 1090 1096 [継承]
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年月日 (必須): 西暦 2013年 12月 26日 (平成 25年 12月 26日) [継承]
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DOI (任意): 10.5114/aoms.2013.39797    (→Scopusで検索) [継承]
PMID (任意): 24482655    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.5114/aoms.2013.39797  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC3902727  (日)    [継承]
4.(英) KeywordList.Keyword: T cell receptor excision circle  (日)    [継承]
5.(英) KeywordList.Keyword: T-cell receptor excision circle  (日)    [継承]
6.(英) KeywordList.Keyword: cell culture  (日)    [継承]
7.(英) KeywordList.Keyword: lymphocytes  (日)    [継承]

標準的な表示

和文冊子 ● Takao Mitsui, Yukiko Kuroda, Shu-ichi Ueono, Naoko Matsui and Ryuji Kaji : FK506 attenuates thymic output in patients with myasthenia gravis, Archives of Medical Science : AMS, Vol.9, No.6, 1090-1096, 2013.
欧文冊子 ● Takao Mitsui, Yukiko Kuroda, Shu-ichi Ueono, Naoko Matsui and Ryuji Kaji : FK506 attenuates thymic output in patients with myasthenia gravis, Archives of Medical Science : AMS, Vol.9, No.6, 1090-1096, 2013.

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