『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=303979EID:303979, Map:0, LastModified:2016年1月29日(金) 11:30:25, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[松井 尚子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Shimizu Fumitaka (日) (読)
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[継承]
2. (英) Omoto Masatoshi (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Sano Yasuteru (日) (読)
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学籍番号 (推奨):
[継承]
4.松井 尚子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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学籍番号 (推奨):
[継承]
5.宮城 愛
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学籍番号 (推奨):
[継承]
6. (英) Tasaki Ayako (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Maeda Toshihiko (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Koga Michiaki (日) (読)
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学籍番号 (推奨):
[継承]
9.梶 龍兒
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学籍番号 (推奨):
[継承]
10. (英) Kanda Takashi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Sera from patients with multifocal motor neuropathy disrupt the blood-nerve barrier  (日)    [継承]
副題 (任意):
要約 (任意): (英) In multifocal motor neuropathy (MMN), the destruction of the blood-nerve barrier (BNB) has been considered to be the key step in the disease process. The purpose of the present study was to ascertain whether sera from patients with MMN can open the BNB, and which component of patient sera is the most important for this disruption. We evaluated the effects of sera from patients with MMN, patients with amyotrophic lateral sclerosis, and control subjects on the expression of tight junction proteins and vascular cell adhesion molecule-1 (VCAM-1), and on the transendothelial electrical resistance (TEER) in human peripheral nerve microvascular endothelial cells (PnMECs). The sera from patients with MMN decreased the claudin-5 protein expression and the TEER in PnMECs. However, this effect was reversed after application of an anti-vascular endothelial growth factor (anti-VEGF) neutralising antibody. The VEGF secreted by PnMECs was significantly increased after exposure to the sera from patients with MMN. The sera from patients with MMN also increased the VCAM-1 protein expression by upregulating the nuclear factor kappa-B (NF-κB) signalling. The immunoglobulin G purified from MMN sera decreased the expression of claudin-5 and increased the VCAM-1 expression in PnMECs. The sera from MMN patients may disrupt the BNB function via the autocrine secretion of VEGF in PnMECs, or the exposure to autoantibodies against PnMECs that are contained in the MMN sera. Autoantibodies against PnMECs in MMN sera may activate the BNB by upregulating the VCAM-1 expression, thereby allowing for the entry of a large number of circulating inflammatory cells into the peripheral nervous system.  (日)    [継承]
キーワード (推奨): 1. (英) Adolescent (日) (読) [継承]
2. (英) Adult (日) (読) [継承]
3. (英) Amyotrophic Lateral Sclerosis (日) (読) [継承]
4. (英) Blood-Nerve Barrier (日) (読) [継承]
5. (英) Case-Control Studies (日) (読) [継承]
6. (英) Cell Culture Techniques (日) (読) [継承]
7. (英) Electric Impedance (日) (読) [継承]
8. (英) Endothelial Cells (日) (読) [継承]
9. (英) Female (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Male (日) (読) [継承]
12. (英) Middle Aged (日) (読) [継承]
13. (英) Polyneuropathies (日) (読) [継承]
14. (英) Serum (日) (読) [継承]
15. (英) Tight Junctions (日) (読) [継承]
16. (英) Vascular Cell Adhesion Molecule-1 (日) (読) [継承]
17. (英) Young Adult (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Neurology, Neurosurgery, and Psychiatry (British Medical Association)
(pISSN: 0022-3050, eISSN: 1468-330X)

ISSN (任意): 1468-330X
ISSN: 0022-3050 (pISSN: 0022-3050, eISSN: 1468-330X)
Title: Journal of neurology, neurosurgery, and psychiatry
Title(ISO): J Neurol Neurosurg Psychiatry
Publisher: BMJ Group
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 85 [継承]
(必須): 5 [継承]
(必須): 526 537 [継承]
都市 (任意):
年月日 (必須): 西暦 2014年 5月 初日 (平成 26年 5月 初日) [継承]
URL (任意):
DOI (任意): 10.1136/jnnp-2013-305405    (→Scopusで検索) [継承]
PMID (任意): 23926278    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000334617800014 [継承]
Scopus (任意): 2-s2.0-84898925618 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1136/jnnp-2013-305405  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) KeywordList.Keyword: BLOOD-BRAIN BARRIER  (日)    [継承]
5.(英) KeywordList.Keyword: IMMUNOLOGY  (日)    [継承]
6.(英) KeywordList.Keyword: NEUROCHEMISTRY  (日)    [継承]
7.(英) KeywordList.Keyword: NEUROMUSCULAR  (日)    [継承]
8.(英) KeywordList.Keyword: NEUROPATHY  (日)    [継承]

標準的な表示

和文冊子 ● Fumitaka Shimizu, Masatoshi Omoto, Yasuteru Sano, Naoko Matsui, Ai Miyashiro, Ayako Tasaki, Toshihiko Maeda, Michiaki Koga, Ryuji Kaji and Takashi Kanda : Sera from patients with multifocal motor neuropathy disrupt the blood-nerve barrier, Journal of Neurology, Neurosurgery, and Psychiatry, Vol.85, No.5, 526-537, 2014.
欧文冊子 ● Fumitaka Shimizu, Masatoshi Omoto, Yasuteru Sano, Naoko Matsui, Ai Miyashiro, Ayako Tasaki, Toshihiko Maeda, Michiaki Koga, Ryuji Kaji and Takashi Kanda : Sera from patients with multifocal motor neuropathy disrupt the blood-nerve barrier, Journal of Neurology, Neurosurgery, and Psychiatry, Vol.85, No.5, 526-537, 2014.

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