『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=303622EID:303622, Map:0, LastModified:2016年1月6日(水) 14:33:47, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[三好 圭子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1.三好 圭子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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2.堀口 大吾 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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3.谷村 綾子
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4. (英) Hagita Hiroko (日) 萩田 浩子 (読)
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5.野間 隆文 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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題名 (必須): (英) Gene Signature of Human Oral Mucosa Fibroblasts: Comparison with Dermal Fibroblasts and Induced Pluripotent Stem Cells.  (日)    [継承]
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要約 (任意): (英) Oral mucosa is a useful material for regeneration therapy with the advantages of its accessibility and versatility regardless of age and gender. However, little is known about the molecular characteristics of oral mucosa. Here we report the first comparative profiles of the gene signatures of human oral mucosa fibroblasts (hOFs), human dermal fibroblasts (hDFs), and hOF-derived induced pluripotent stem cells (hOF-iPSCs), linking these with biological roles by functional annotation and pathway analyses. As a common feature of fibroblasts, both hOFs and hDFs expressed glycolipid metabolism-related genes at higher levels compared with hOF-iPSCs. Distinct characteristics of hOFs compared with hDFs included a high expression of glycoprotein genes, involved in signaling, extracellular matrix, membrane, and receptor proteins, besides a low expression of HOX genes, the hDFs-markers. The results of the pathway analyses indicated that tissue-reconstructive, proliferative, and signaling pathways are active, whereas senescence-related genes in p53 pathway are inactive in hOFs. Furthermore, more than half of hOF-specific genes were similarly expressed to those of hOF-iPSC genes and might be controlled by WNT signaling. Our findings demonstrated that hOFs have unique cellular characteristics in specificity and plasticity. These data may provide useful insight into application of oral fibroblasts for direct reprograming.  (日)    [継承]
キーワード (推奨):
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誌名 (必須): BioMed Research International (Hindawi Pub. Co.)
(pISSN: 2314-6133, eISSN: 2314-6141)

ISSN (任意): 2314-6141
ISSN: 2314-6133 (pISSN: 2314-6133, eISSN: 2314-6141)
Title: BioMed research international
Title(ISO): Biomed Res Int
Publisher: Hindawi
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 2015 [継承]
(必須): [継承]
(必須): 121575 121575 [継承]
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年月日 (必須): 西暦 2015年 8月 3日 (平成 27年 8月 3日) [継承]
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DOI (任意): 10.1155/2015/121575    (→Scopusで検索) [継承]
PMID (任意): 26339586    (→Scopusで検索) [継承]
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WOS (任意): 000359570500001 [継承]
Scopus (任意): 2-s2.0-84939816295 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1155/2015/121575  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC4538314  (日)    [継承]

標準的な表示

和文冊子 ● Keiko Miyoshi, Taigo Horiguchi, Ayako Tanimura, Hiroko Hagita and Takafumi Noma : Gene Signature of Human Oral Mucosa Fibroblasts: Comparison with Dermal Fibroblasts and Induced Pluripotent Stem Cells., BioMed Research International, Vol.2015, 121575, 2015.
欧文冊子 ● Keiko Miyoshi, Taigo Horiguchi, Ayako Tanimura, Hiroko Hagita and Takafumi Noma : Gene Signature of Human Oral Mucosa Fibroblasts: Comparison with Dermal Fibroblasts and Induced Pluripotent Stem Cells., BioMed Research International, Vol.2015, 121575, 2015.

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