『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=303561EID:303561, Map:0, LastModified:2015年9月5日(土) 18:38:34, Operator:[三宅 雅人], Avail:TRUE, Censor:0, Owner:[三宅 雅人], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.三宅 雅人 ([徳島大学.先端酵素学研究所.重点研究部門])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Takahashi Hideyuki (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Kitagawa Eri (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Watanabe Hitoshi (日) (読)
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[継承]
5. (英) Sakurada Takahiro (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Aso Hisashi (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Yamaguchi Takahiro (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) AMPK activation by AICAR inhibits myogenic differentiation and myostatin expression in cattle.  (日)    [継承]
副題 (任意):
要約 (任意): (英) AMP-activated protein kinase (AMPK) regulates metabolism in skeletal muscle, and myostatin (MSTN) negatively regulates skeletal muscle development and growth. In the present study, AMPK activation and the relationship between AMPK and MSTN during myogenic differentiation were investigated in cultures derived from bovine skeletal muscle. Myoblasts capable of forming myotubes were obtained from bovine skeletal muscle and treated with AICAR to activate AMPK, resulting in suppressed myotube formation. AICAR treatment significantly reduced the expression of MSTN mRNA during myogenic differentiation. Combined treatment with AICAR and MSTN suppressed myotube formation to a greater extent than AICAR alone. SB431542, an inhibitor of MSTN signaling, promoted myotube formation during myogenic differentiation. However, simultaneous treatment with AICAR blocked this effect of SB431542. Therefore, AMPK activation inhibits myogenic differentiation but may suppress MSTN expression to balance muscle development.  (日)    [継承]
キーワード (推奨): 1. (英) AMP-Activated Protein Kinases (日) (読) [継承]
2. (英) Aminoimidazole Carboxamide (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Cattle (日) (読) [継承]
5. (英) Cell Culture Techniques (日) (読) [継承]
6. (英) Cell Differentiation (日) (読) [継承]
7. (英) Down-Regulation (日) (読) [継承]
8. (英) Enzyme Activation (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Muscle Fibers, Skeletal (日) (読) [継承]
11. (英) Myoblasts (日) (読) [継承]
12. (英) Myostatin (日) (読) [継承]
13. (英) RNA, Messenger (日) (読) [継承]
14. (英) Ribonucleotides (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cell and Tissue Research ([Springer-Verlag])
(pISSN: 0302-766X, eISSN: 1432-0878)

ISSN (任意): 1432-0878
ISSN: 0302-766X (pISSN: 0302-766X, eISSN: 1432-0878)
Title: Cell and tissue research
Title(ISO): Cell Tissue Res
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 349 [継承]
(必須): 2 [継承]
(必須): 615 623 [継承]
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年月日 (必須): 西暦 2012年 5月 24日 (平成 24年 5月 24日) [継承]
URL (任意):
DOI (任意): 10.1007/s00441-012-1422-8    (→Scopusで検索) [継承]
PMID (任意): 22622802    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Masato Miyake, Hideyuki Takahashi, Eri Kitagawa, Hitoshi Watanabe, Takahiro Sakurada, Hisashi Aso and Takahiro Yamaguchi : AMPK activation by AICAR inhibits myogenic differentiation and myostatin expression in cattle., Cell and Tissue Research, Vol.349, No.2, 615-623, 2012.
欧文冊子 ● Masato Miyake, Hideyuki Takahashi, Eri Kitagawa, Hitoshi Watanabe, Takahiro Sakurada, Hisashi Aso and Takahiro Yamaguchi : AMPK activation by AICAR inhibits myogenic differentiation and myostatin expression in cattle., Cell and Tissue Research, Vol.349, No.2, 615-623, 2012.

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