| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Takahashi H (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Sato K (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Yamaguchi T (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 三宅 雅人 ([徳島大学.先端酵素学研究所.重点研究部門])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Watanabe H (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Nagasawa Y (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Kitagawa E (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Terada S (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | (英) Urakawa M (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 10. | (英) Rose T. M (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 11. | (英) McMahon D. C (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 12. | (英) Watanabe K (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 13. | (英) Ohwada S (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 14. | (英) Gotoh T (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 15. | (英) Aso H (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Myostatin alters glucose transporter-4 (GLUT4) expression in bovine skeletal muscles and myoblasts isolated from double-muscled (DM) and normal-muscled (NM) Japanese shorthorn cattle. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The purpose of this study was to determine whether myostatin alters glucose transporter-4 (GLUT4) expression in bovine skeletal muscles and myoblasts isolated from double-muscled (DM) and normal-muscled (NM) Japanese Shorthorn cattle. Plasma concentrations of glucose were lower in DM cattle than in NM cattle (P < 0.01). The expression of GLUT4 messenger RNA (mRNA) in the skeletal muscle ex vivo and in myoblasts at 72 h after differentiation in vitro was higher in DM cattle than in NM cattle (P < 0.01). In contrast, the NM and DM cattle did not differ with respect to skeletal muscle expression of GLUT1 and myocyte enhancer factor-2c (MEF2c), a transcription factor of GLUT4. In differentiated myoblasts, the expression of GLUT1, GLUT4, and MEF2c mRNAs was greater in DM cattle than in NM cattle (P < 0.01). In the presence and absence of insulin, glucose uptake in myoblasts was increased in DM cattle relative to that of NM cattle (P < 0.01). The addition of myostatin decreased the expression of GLUT4 and MEF2c mRNAs in DM myoblasts (P < 0.05). Results of the present study suggest that myostatin inhibits the expression of GLUT4 mRNA possibly via MEF2c and that the greater ability of the DM cattle to produce muscle relative to the NM cattle may be due to their greater sensitivity to insulin and greater use of glucose. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
| [継承] |
| 2. | (英) Blood Glucose (日) (読)
| [継承] |
| 3. | (英) Cattle (日) (読)
| [継承] |
| 4. | (英) Gene Expression Regulation (日) (読)
| [継承] |
| 5. | (英) Glucose Tolerance Test (日) (読)
| [継承] |
| 6. | (英) Glucose Transporter Type 4 (日) (読)
| [継承] |
| 7. | (英) Insulin (日) (読)
| [継承] |
| 8. | (英) Muscle, Skeletal (日) (読)
| [継承] |
| 9. | (英) Myoblasts (日) (読)
| [継承] |
| 10. | (英) Myostatin (日) (読)
| [継承] |
| 11. | (英) RNA, Messenger (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Domestic Animal Endocrinology ([Elsevier])
(pISSN: 0739-7240, eISSN: 1879-0054)
| ○ISSN (任意): | □ | 1879-0054
ISSN: 0739-7240
(pISSN: 0739-7240, eISSN: 1879-0054) Title: Domestic animal endocrinologyTitle(ISO): Domest Anim EndocrinolPublisher: Elsevier BV (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 48
| [継承] |
| ○号 (必須): |
| ○頁 (必須): | □ | 62 68
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2014年 2月 10日 (平成 26年 2月 10日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.domaniend.2014.01.007 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 24906930 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.domaniend.2014.01.007 (日)
| [継承] |
| 2. | (英) Article.ELocationID: S0739-7240(14)00008-3 (日)
| [継承] |
| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
| [継承] |
| 5. | (英) KeywordList.Keyword: Double-muscled Japanese shorthorn (日)
| [継承] |
| 6. | (英) KeywordList.Keyword: GLUT-1 (日)
| [継承] |
| 7. | (英) KeywordList.Keyword: GLUT-4 (日)
| [継承] |
| 8. | (英) KeywordList.Keyword: Glucose uptake (日)
| [継承] |
| 9. | (英) KeywordList.Keyword: MEF2c (日)
| [継承] |