『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=301588EID:301588, Map:0, LastModified:2021年8月12日(木) 14:04:10, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[山本 圭], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Tsboi K. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Sugimoto Y. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Iwane A. (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4.山本 圭 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.食料科学講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Yamamoto S. (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Ichikawa A. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) PG production in uterine tissues is important for many physiological processes in late pregnancy, including parturition. We examined the expression of the PGH2 synthases, cyclooxygenase-1 (COX-1) and COX-2, in uterine tissues during late pregnancy, using PGF receptor-deficient (FP-/-) mice. Female FP-/- mice are unable to deliver normal fetuses at term, as they do not undergo luteolysis necessary for parturition. In wild-type mice, COX-1 messenger RNA (mRNA) was expressed in the endometrial epithelium, myometrium, and decidua throughout late pregnancy. The expression of COX-1 mRNA in the endometrial epithelium and myometrium decreased both in wild-type mice undergoing natural parturition and in FP-/- mice undergoing ovariectomy-induced parturition, but expression of COX-1 mRNA was enhanced in FP-/- mice at the expected term. In wild-type mice, COX-2 mRNA was not expressed in the myometrium before parturition, but was markedly induced during parturition. This induction of COX-2 was absent in FP-/- mice at the expected term, but was found during ovariectomy-induced parturition in these mice. Expression of COX-2 proteins was confirmed by immunohistochemical analysis. Thus, in uterine tissues, myometrial expression of COX-2 is closely associated with the occurrence of parturition, but uterine expression of COX-1 is induced much earlier and kept at a high level until parturition occurs. These results suggest that COX-1-derived PGs are responsible for the induction of luteolysis, and that COX-2-derived PGs play a role in the final pathway of parturition.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blotting, Northern (日) (読) [継承]
3. (英) Corpus Luteum (日) (読) [継承]
4. (英) Cyclooxygenase 1 (日) (読) [継承]
5. (英) Cyclooxygenase 2 (日) (読) [継承]
6. (英) Estradiol (日) (読) [継承]
7. (英) Female (日) (読) [継承]
8. (英) Immunohistochemistry (日) (読) [継承]
9. (英) In Situ Hybridization (日) (読) [継承]
10. (英) Isoenzymes (日) (読) [継承]
11. (英) Labor, Obstetric (日) (読) [継承]
12. (英) Membrane Proteins (日) (読) [継承]
13. (英) Mice (日) (読) [継承]
14. (英) Mice, Inbred C57BL (日) (読) [継承]
15. (英) Mice, Knockout (日) (読) [継承]
16. (英) Myometrium (日) (読) [継承]
17. (英) Ovariectomy (日) (読) [継承]
18. (英) Pregnancy (日) (読) [継承]
19. (英) Pregnancy, Animal (日) (読) [継承]
20. (英) Progesterone (日) (読) [継承]
21. (英) Prostaglandin-Endoperoxide Synthases (日) (読) [継承]
22. (英) Receptors, Prostaglandin (日) (読) [継承]
23. (英) Uterus (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 141 [継承]
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都市 (任意):
年月日 (必須): 西暦 2000年 1月 初日 (平成 12年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1210/endo.141.1.7236    (→Scopusで検索) [継承]
PMID (任意): 10614653    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-0034463047 [継承]
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被引用数 (任意):
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● K. Tsboi, Y. Sugimoto, A. Iwane, Kei Yamamoto, S. Yamamoto and A. Ichikawa : Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient mice., Endocrinology, Vol.141, No.1, 315-324, 2000.
欧文冊子 ● K. Tsboi, Y. Sugimoto, A. Iwane, Kei Yamamoto, S. Yamamoto and A. Ichikawa : Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient mice., Endocrinology, Vol.141, No.1, 315-324, 2000.

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