『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1. (英) Ikawa H (日) (読)
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2.山本 圭 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生命科学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命コース])
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3. (英) Takahashi Y (日) (読)
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4. (英) Ueda N (日) (読)
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5. (英) Hayashi Y (日) (読)
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6. (英) Yamamoto S (日) (読)
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7. (英) Ishimura K (日) (読)
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8. (英) Irahara M (日) (読)
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9. (英) Aono T (日) (読)
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○題名 (必須): □(英) Arachidonate 12-lipoxygenase in porcine anterior pituitary cells; its localization and possible function in gonadotrophs.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Arachidonate 12-lipoxygenase, which oxygenates positions 12 and 13 of arachidonic and linoleic acids, is present in porcine anterior pituitary cells. Colocalization of the 12-lipoxygenase with various pituitary hormones was examined by immunohistochemical double-staining using antibodies against 12-lipoxygenase and various anterior pituitary hormones. Under light microscopy, approximately 7% of the cells producing luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were positive for 12-lipoxygenase, whereas the enzyme was detected in less than 2% of the cells producing thyrotrophin, prolactin, growth hormone (GH), and adrenocorticotrophin. In an attempt to examine the participation of 12-lipoxygenase metabolites in pituitary hormone release, we incubated the primary culture of porcine anterior pituitary cells with 12-hydroperoxy-arachidonic acid or 13-hydroperoxy-linoleic acid. Significant stimulation of LH and FSH release by these hydroperoxides was observed at 10 microM in a time-dependent manner. At doses around 10 microM these compounds produced responses of similar magnitude to 1 nM gonadotrophin-releasing hormone (GnRH), but higher concentrations (30 microM) of the compounds were required for GH release. In contrast, 12-hydroxy-arachidonic and 13-hydroxy-linoleic acids were almost ineffective. Furthermore, the gonadotrophin release by 1 nM GnRH was inhibited by nordihydroguaiaretic acid (a lipoxygenase inhibitor) with an IC50 of about 5 microM. Thus, the hydroperoxy (but not hydroxy) products of 12-lipoxygenase may be involved in the release of pituitary hormones especially LH and FSH.  (日)    [継承]
○キーワード (推奨): 1. (英) 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antithrombins (日) (読) [継承]
4. (英) Arachidonate 12-Lipoxygenase (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Chromatography, High Pressure Liquid (日) (読) [継承]
7. (英) Fatty Acids, Unsaturated (日) (読) [継承]
8. (英) Follicle Stimulating Hormone (日) (読) [継承]
9. (英) Gonadotropin-Releasing Hormone (日) (読) [継承]
10. (英) Growth Hormone (日) (読) [継承]
11. (英) Hydroxyeicosatetraenoic Acids (日) (読) [継承]
12.免疫組織化学 (immunohistochemistry) [継承]
13. (英) Leukotrienes (日) (読) [継承]
14. (英) Linoleic Acids (日) (読) [継承]
15. (英) Lipid Peroxides (日) (読) [継承]
16. (英) Luteinizing Hormone (日) (読) [継承]
17. (英) Pituitary Gland, Anterior (日) (読) [継承]
18. (英) Swine (日) (読) [継承]
19. (英) Time Factors (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □The Journal of Endocrinology (Society for Endocrinology)
(pISSN: 0022-0795, eISSN: 1479-6805)

○ISSN (任意): □0022-0795
ISSN: 0022-0795 (pISSN: 0022-0795, eISSN: 1479-6805)
Title: The Journal of endocrinology
Title(ISO): J Endocrinol
Publisher: Society for Endocrinology
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □148 [継承]
○号 (必須): □ [継承]
○頁 (必須): □33 41 [継承]
○都市 (任意):
○年月日 (必須): □西暦 1996年 1月 初日 (平成 8年 1月 初日) [継承]
○URL (任意):
○DOI (任意): □10.1677/joe.0.1480033    (→Scopusで検索) [継承]
○PMID (任意): □8568469    (→Scopusで検索) [継承]
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○Scopus (任意): □2-s2.0-0030033696 [継承]
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○備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● H Ikawa, Kei Yamamoto, Y Takahashi, N Ueda, Y Hayashi, S Yamamoto, K Ishimura, M Irahara and T Aono : Arachidonate 12-lipoxygenase in porcine anterior pituitary cells; its localization and possible function in gonadotrophs., The Journal of Endocrinology, 148, 33-41, 1996.
欧文冊子 ● H Ikawa, Kei Yamamoto, Y Takahashi, N Ueda, Y Hayashi, S Yamamoto, K Ishimura, M Irahara and T Aono : Arachidonate 12-lipoxygenase in porcine anterior pituitary cells; its localization and possible function in gonadotrophs., The Journal of Endocrinology, 148, 33-41, 1996.

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