『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=301264)

EID=301264EID:301264, Map:0, LastModified:2015年9月4日(金) 14:05:34, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[吉田 守美子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Parker-Duffen Jennifer L (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Nakamura Kazuto (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Silver Marcy (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Kikuchi Ryosuke (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Tigges Ulrich (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.吉田 守美子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.血液・内分泌代謝内科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Denzel Martin S (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Ranscht Barbara (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Walsh Kenneth (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) T-cadherin is essential for adiponectin-mediated revascularization.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Adipose tissue secretes protein factors that have systemic actions on cardiovascular tissues. Previous studies have shown that ablation of the adipocyte-secreted protein adiponectin leads to endothelial dysfunction, whereas its overexpression promotes wound healing. However, the receptor(s) mediating the protective effects of adiponectin on the vasculature is not known. Here we examined the role of membrane protein T-cadherin, which localizes adiponectin to the vascular endothelium, in the revascularization response to chronic ischemia. T-cadherin-deficient mice were analyzed in a model of hind limb ischemia where blood flow is surgically disrupted in one limb and recovery is monitored over 28 days by laser Doppler perfusion imaging. In this model, T-cadherin-deficient mice phenocopy adiponectin-deficient mice such that both strains display an impaired blood flow recovery compared with wild-type controls. Delivery of exogenous adiponectin rescued the impaired revascularization phenotype in adiponectin-deficient mice but not in T-cadherin-deficient mice. In cultured endothelial cells, T-cadherin deficiency by siRNA knockdown prevented the ability of adiponectin to promote cellular migration and proliferation. These data highlight a previously unrecognized role for T-cadherin in limb revascularization and show that it is essential for mediating the vascular actions of adiponectin.  (日)    [継承]
キーワード (推奨): 1. (英) Adiponectin (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cadherins (日) (読) [継承]
4. (英) Endothelium, Vascular (日) (読) [継承]
5. (英) Gene Knockdown Techniques (日) (読) [継承]
6. (英) Hindlimb (日) (読) [継承]
7.虚血 (ischemia) [継承]
8.ノックアウトマウス (knockout mice) [継承]
9.ノックアウトマウス (knockout mice) [継承]
10. (英) Neovascularization, Physiologic (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 1083-351X
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 288 [継承]
(必須): 34 [継承]
(必須): 24886 24897 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 7月 3日 (平成 25年 7月 3日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.M113.454835    (→Scopusで検索) [継承]
PMID (任意): 23824191    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]

標準的な表示

和文冊子 ● L Jennifer Parker-Duffen, Kazuto Nakamura, Marcy Silver, Ryosuke Kikuchi, Ulrich Tigges, Sumiko Yoshida, S Martin Denzel, Barbara Ranscht and Kenneth Walsh : T-cadherin is essential for adiponectin-mediated revascularization., The Journal of Biological Chemistry, Vol.288, No.34, 24886-24897, 2013.
欧文冊子 ● L Jennifer Parker-Duffen, Kazuto Nakamura, Marcy Silver, Ryosuke Kikuchi, Ulrich Tigges, Sumiko Yoshida, S Martin Denzel, Barbara Ranscht and Kenneth Walsh : T-cadherin is essential for adiponectin-mediated revascularization., The Journal of Biological Chemistry, Vol.288, No.34, 24886-24897, 2013.

関連情報

Number of session users = 3, LA = 1.55, Max(EID) = 373386, Max(EOID) = 999142.