『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=300752)

EID=300752EID:300752, Map:0, LastModified:2017年10月12日(木) 13:22:21, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[武川 大輔], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.武川 大輔 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.平尾 功治 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.高橋 加奈子
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.松尾 敬志
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Modulatory roles of interferon-γ through indoleamine 2, 3-dioxygenase induction in innate immune response of dental pulp cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Marked infiltration of inflammatory cells such as activated T cells producing interferon-γ (IFN-γ) is observed in severe pulpitis. However, the roles of IFN-γ in the innate immune response of dental pulp have not been reported. Indoleamine 2, 3-dioxygenase (IDO) is a regulator of immune responses, and the IDO expression is induced by IFN-γ in many cells whose expression in dental pulp is unknown. The purpose of this study was to determine the role of IFN-γ in the immune response through microbial pattern recognition receptors (PRRs) such as Toll-like receptors or nucleotide-binding oligomerization domain-like receptors on the production of proinflammatory cytokines such as CXCL10 and interleukin (IL)-6 and the expression of IDO in cultured human dental pulp cells (HDPCs). HDPCs were established from explant cultures of healthy pulp tissues. CXCL10 and IL-6 production was determined using enzyme-linked immunosorbent assay. Confirmation of IDO localization in dental pulp tissues was examined using immunohistochemistry. IDO expression in HDPCs was analyzed by immunoblot. IFN-γ significantly up-regulated CXCL10 and IL-6 production in the HDPCs stimulated with ligands for PRRs in a concentration-dependent manner. The expression of IDO was detected in inflamed pulp tissue. In addition, IFN-γ in combination with the PRR ligands enhanced IDO expression in HDPCs compared with IFN-γ alone. Moreover, CXCL10 production in IFN-γ-stimulated HDPCs was inhibited by an IDO inhibitor. This study showed the synergistic effects by IFN-γ on cytokine production and IDO expression in HDPCs, suggesting that IFN-γ may modulate the innate immune response of dental pulp.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): Journal of Endodontics ([The American Association of Endodontics])
(pISSN: 0099-2399, eISSN: 1878-3554)

ISSN (任意): 1878-3554
ISSN: 0099-2399 (pISSN: 0099-2399, eISSN: 1878-3554)
Title: Journal of endodontics
Title(ISO): J Endod
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 40 [継承]
(必須): 9 [継承]
(必須): 1382 1387 [継承]
都市 (任意):
年月日 (必須): 西暦 2014年 5月 9日 (平成 26年 5月 9日) [継承]
URL (任意):
DOI (任意): 10.1016/j.joen.2014.03.018    (→Scopusで検索) [継承]
PMID (任意): 25146019    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-85027943562 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.joen.2014.03.018  (日)    [継承]
2.(英) Article.ELocationID: S0099-2399(14)00314-8  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) KeywordList.Keyword: CXCL10  (日)    [継承]
6.(英) KeywordList.Keyword: Toll-like receptors  (日)    [継承]
7.(英) KeywordList.Keyword: indoleamine 2, 3-dioxygenase  (日)    [継承]
8.(英) KeywordList.Keyword: interleukin6  (日)    [継承]
9.(英) KeywordList.Keyword: nucleotide-binding oligomerization domain  (日)    [継承]
10.(英) KeywordList.Keyword: pattern recognition receptors  (日)    [継承]
11.(英) KeywordList.Keyword: pulpitis  (日)    [継承]

標準的な表示

和文冊子 ● Daisuke Takegawa, Tadashi Nakanishi, Kouji Hirao, Hiromichi Yumoto, Kanako Takahashi and Takashi Matsuo : Modulatory roles of interferon-γ through indoleamine 2, 3-dioxygenase induction in innate immune response of dental pulp cells., Journal of Endodontics, Vol.40, No.9, 1382-1387, 2014.
欧文冊子 ● Daisuke Takegawa, Tadashi Nakanishi, Kouji Hirao, Hiromichi Yumoto, Kanako Takahashi and Takashi Matsuo : Modulatory roles of interferon-γ through indoleamine 2, 3-dioxygenase induction in innate immune response of dental pulp cells., Journal of Endodontics, Vol.40, No.9, 1382-1387, 2014.

関連情報

Number of session users = 0, LA = 0.62, Max(EID) = 360929, Max(EOID) = 966657.