『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=300228)

EID=300228EID:300228, Map:0, LastModified:2015年9月12日(土) 18:24:59, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[岡村 永一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Takahashi Takuya (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Matsuzaki Hitomi (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Tomizawa Shin-Ichi (日) (読)
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[継承]
4.岡村 永一
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[継承]
5. (英) Ichiyanagi Tomoko (日) (読)
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6. (英) Fukamizu Akiyoshi (日) (読)
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7. (英) Sasaki Hiroyuki (日) (読)
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[継承]
8. (英) Tanimoto Keiji (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Allele-specific methylation of the endogenous H19 imprinting control region (ICR) is established in sperm. We previously showed that the paternal H19 ICR in yeast artificial chromosome (YAC) transgenic mice (TgM) was preferentially methylated in somatic cells, but not in germ cells, suggesting that differential methylation could be established after fertilization. In this report, we discovered small RNA molecules in growing oocytes, the nucleotide sequences of which mapped to the H19 ICR. To test if these small RNA sequences play a role in the establishment of differential methylation, we deleted the sequences from the H19 ICR DNA and generated YAC TgM. In somatic cells of these mice, methylation imprinting of the transgene was normally established. In addition, the mutant fragment was not methylated in sperm and eggs. These data demonstrate that sequences in the H19 ICR that correspond to the small RNA sequences are dispensable for methylation imprinting in YAC TgM.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blotting, Southern (日) (読) [継承]
3. (英) Cells, Cultured (日) (読) [継承]
4. (英) Chromosomes, Artificial, Yeast (日) (読) [継承]
5. (英) DNA Methylation (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Fertilization (日) (読) [継承]
8. (英) Genomic Imprinting (日) (読) [継承]
9. (英) Locus Control Region (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Transgenic (日) (読) [継承]
13. (英) Oocytes (日) (読) [継承]
14. (英) RNA, Long Noncoding (日) (読) [継承]
15. (英) RNA, Small Untranslated (日) (読) [継承]
16. (英) RNA, Untranslated (日) (読) [継承]
17. (英) Testis (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Gene ([Elsevier Science B.V.])
(pISSN: 0378-1119, eISSN: 1879-0038)

ISSN (任意): 1879-0038
ISSN: 0378-1119 (pISSN: 0378-1119, eISSN: 1879-0038)
Title: Gene
Title(ISO): Gene
Publisher: Elsevier B.V.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 508 [継承]
(必須): 1 [継承]
(必須): 26 34 [継承]
都市 (任意):
年月日 (必須): 西暦 2012年 8月 4日 (平成 24年 8月 4日) [継承]
URL (任意):
DOI (任意): 10.1016/j.gene.2012.07.062    (→Scopusで検索) [継承]
PMID (任意): 22890135    (→Scopusで検索) [継承]
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指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.gene.2012.07.062  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takuya Takahashi, Hitomi Matsuzaki, Shin-Ichi Tomizawa, Eiichi Okamura, Tomoko Ichiyanagi, Akiyoshi Fukamizu, Hiroyuki Sasaki and Keiji Tanimoto : Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice., Gene, Vol.508, No.1, 26-34, 2012.
欧文冊子 ● Takuya Takahashi, Hitomi Matsuzaki, Shin-Ichi Tomizawa, Eiichi Okamura, Tomoko Ichiyanagi, Akiyoshi Fukamizu, Hiroyuki Sasaki and Keiji Tanimoto : Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice., Gene, Vol.508, No.1, 26-34, 2012.

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