『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=300225)

EID=300225EID:300225, Map:0, LastModified:2015年9月12日(土) 21:40:31, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[岡村 永一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.岡村 永一
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Matsuzaki Hitomi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Campbell D. Andrew (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Engel Douglas James (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Fukamizu Akiyoshi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Tanimoto Keiji (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) In primitive erythroid cells of human beta-globin locus transgenic mice (TgM), the locus control region (LCR)-proximal epsilon- and gamma-globin genes are transcribed, whereas the distal delta- and beta-globin genes are silent. It is generally accepted that the beta-globin gene is competitively suppressed by gamma-globin gene expression at this developmental stage. Previously, however, we observed that epsilon-globin gene expression was severely attenuated when its distance from the LCR was extended, implying that beta-globin gene might also be silenced because of its great distance from the LCR. Here, to clarify the beta-globin gene silencing mechanism, we established TgM lines carrying either gamma- or epsilon- plus gamma-globin promoter deletions, without significantly altering the distance between the beta-globin gene and the LCR. Precocious expression of delta- and beta-globin genes was observed in primitive erythroid cells of mutant, but not wild-type TgM, which was most evident when both the epsilon and gamma promoters were deleted. Thus, we clearly demonstrated that the repression of the delta- and beta-globin genes in primitive erythroid cells is dominated by competitive silencing by the epsilon- and gamma-globin gene promoters, and that epsilon- and the other beta-like globin genes might be activated by two distinct mechanisms by the LCR.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Chromosomes, Artificial, Yeast (日) (読) [継承]
3. (英) Erythroid Cells (日) (読) [継承]
4. (英) Gene Expression Regulation (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Locus Control Region (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Mice, Transgenic (日) (読) [継承]
9. (英) Saccharomyces cerevisiae (日) (読) [継承]
10. (英) beta-Globins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The FASEB journal ([Federation of American Societies for Experimental Biology])
(pISSN: 0892-6638, eISSN: 1530-6860)

ISSN (任意): 1530-6860
ISSN: 0892-6638 (pISSN: 0892-6638, eISSN: 1530-6860)
Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Title(ISO): FASEB J
Supplier: Federation of American Societies for Experimental Biology
Publisher: Federation of American Societies for Experimental Biology
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 23 [継承]
(必須): 12 [継承]
(必須): 4335 4343 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 8月 18日 (平成 21年 8月 18日) [継承]
URL (任意):
DOI (任意): 10.1096/fj.09-137778    (→Scopusで検索) [継承]
PMID (任意): 19690216    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1096/fj.09-137778  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) OtherID: PMC2812047  (日)    [継承]

標準的な表示

和文冊子 ● Eiichi Okamura, Hitomi Matsuzaki, Andrew D. Campbell, James Douglas Engel, Akiyoshi Fukamizu and Keiji Tanimoto : All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice., The FASEB journal, Vol.23, No.12, 4335-4343, 2009.
欧文冊子 ● Eiichi Okamura, Hitomi Matsuzaki, Andrew D. Campbell, James Douglas Engel, Akiyoshi Fukamizu and Keiji Tanimoto : All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice., The FASEB journal, Vol.23, No.12, 4335-4343, 2009.

関連情報

Number of session users = 0, LA = 0.55, Max(EID) = 405196, Max(EOID) = 1098795.