『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=299875EID:299875, Map:0, LastModified:2015年10月30日(金) 16:41:25, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[後東 久嗣], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.青野 純典 ([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.先端医療創生科学講座.呼吸器・膠原病内科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kishi Masami (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Yokota Yuki (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4.東 桃代 ([徳島大学.病院.中央診療施設等.感染制御部])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Kinoshita Katsuhiro (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Takezaki Akio (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Sato Seidai (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8.河野 弘 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域リウマチ・総合内科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9.岸 潤
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貢献度 (任意):
学籍番号 (推奨):
[継承]
10.後東 久嗣
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貢献度 (任意):
学籍番号 (推奨):
[継承]
11. (英) Uehara Hisanori (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
12. (英) Izumi Keisuke (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
13.西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Role of PDGF/PDGFR axis in the trafficking of circulating fibrocytes in pulmonary fibrosis  (日)    [継承]
副題 (任意):
要約 (任意): (英) Circulating fibrocytes have been reported to migrate into the injured lungs, and contribute to fibrogenesis via CXCL12-CXCR4 axis. In contrast, we report that imatinib mesylate prevented bleomycin (BLM)-induced pulmonary fibrosis in mice by inhibiting platelet-derived growth factor receptor (PDGFR), even when it was administered only in the early phase. The goal of this study was to test the hypothesis that platelet-derived growth factor (PDGF) might directly contribute to the migration of fibrocytes to the injured lungs. PDGFR expression in fibrocytes was examined by flow cytometry and RT-PCR. The migration of fibrocytes was evaluated by using a chemotaxis assay for human fibrocytes isolated from peripheral blood. The numbers of fibrocytes triple-stained for CD45, collagen-1, and CXCR4 were also examined in lung digests of BLM-treated mice. PDGFR mRNA levels in fibrocytes isolated from patients with idiopathic pulmonary fibrosis were investigated by real-time PCR. Fibrocytes expressed both PDGFR-α and -β, and migrated in response to PDGFs. PDGFR inhibitors (imatinib, PDGFR-blocking antibodies) suppressed fibrocyte migration in vitro, and reduced the number of fibrocytes in the lungs of BLM-treated mice. PDGF-BB was a stronger chemoattractant than the other PDGFs in vitro, and anti-PDGFR-β-blocking antibody decreased the numbers of fibrocytes in the lungs compared with anti-PDGFR-α antibody in vivo. Marked expression of PDGFR-β was observed in fibrocytes from patients with idiopathic pulmonary fibrosis compared with healthy subjects. These results suggest that PDGF directly functions as a strong chemoattractant for fibrocytes. In particular, the PDGF-BB-PDGFR-β biological axis might play a critical role in fibrocyte migration into the fibrotic lungs.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Benzamides (日) (読) [継承]
3. (英) Case-Control Studies (日) (読) [継承]
4. (英) Chemotaxis (日) (読) [継承]
5. (英) Drug Evaluation, Preclinical (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Injections, Intraperitoneal (日) (読) [継承]
9. (英) Mice, Inbred C57BL (日) (読) [継承]
10. (英) Piperazines (日) (読) [継承]
11. (英) Platelet-Derived Growth Factor (日) (読) [継承]
12.肺線維症 (pulmonary fibrosis) [継承]
13. (英) Pyrimidines (日) (読) [継承]
14. (英) Receptor, Platelet-Derived Growth Factor beta (日) (読) [継承]
15. (英) Receptors, CXCR4 (日) (読) [継承]
16.シグナル伝達 (signal transduction) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Respiratory Cell and Molecular Biology (American Thoracic Society/American Lung Association)
(pISSN: 1044-1549, eISSN: 1535-4989)

ISSN (任意): 1535-4989
ISSN: 1044-1549 (pISSN: 1044-1549, eISSN: 1535-4989)
Title: American journal of respiratory cell and molecular biology
Title(ISO): Am J Respir Cell Mol Biol
Publisher: American Thoracic Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 51 [継承]
(必須): 6 [継承]
(必須): 793 801 [継承]
都市 (任意):
年月日 (必須): 西暦 2014年 12月 1日 (平成 26年 12月 1日) [継承]
URL (任意):
DOI (任意): 10.1165/rcmb.2013-0455OC    (→Scopusで検索) [継承]
PMID (任意): 24885373    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000347419700008 [継承]
Scopus (任意): 2-s2.0-84918792291 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1165/rcmb.2013-0455OC  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) KeywordList.Keyword: fibrocyte  (日)    [継承]
5.(英) KeywordList.Keyword: lung fibrosis  (日)    [継承]
6.(英) KeywordList.Keyword: platelet-derived growth factor  (日)    [継承]

標準的な表示

和文冊子 ● Yoshinori Aono, Masami Kishi, Yuki Yokota, Momoyo Azuma, Katsuhiro Kinoshita, Akio Takezaki, Seidai Sato, Hiroshi Kawano, Jun Kishi, Hisatsugu Goto, Hisanori Uehara, Keisuke Izumi and Yasuhiko Nishioka : Role of PDGF/PDGFR axis in the trafficking of circulating fibrocytes in pulmonary fibrosis, American Journal of Respiratory Cell and Molecular Biology, Vol.51, No.6, 793-801, 2014.
欧文冊子 ● Yoshinori Aono, Masami Kishi, Yuki Yokota, Momoyo Azuma, Katsuhiro Kinoshita, Akio Takezaki, Seidai Sato, Hiroshi Kawano, Jun Kishi, Hisatsugu Goto, Hisanori Uehara, Keisuke Izumi and Yasuhiko Nishioka : Role of PDGF/PDGFR axis in the trafficking of circulating fibrocytes in pulmonary fibrosis, American Journal of Respiratory Cell and Molecular Biology, Vol.51, No.6, 793-801, 2014.

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