| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○組織 (推奨): | 1. | 徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学 (2015年4月1日〜)
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| ○著者 (必須): | 1. | (英) Sano Tomomi (日) (読)
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| 2. | (英) Iwashita Misaki (日) (読)
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| 3. | (英) Nagayasu Nagayasu (日) (読)
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| 4. | (英) Yamashita Akiko (日) (読)
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| 5. | (英) Shinjo Takanori (日) (読)
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| 6. | (英) Hashikata Atsushi (日) (読)
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| 7. | (英) Asano Tomoichiro (日) (読)
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| 8. | (英) Kushiyama Akifumi (日) (読)
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| 9. | 石丸 直澄 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| 10. | 高浜 洋介
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| 11. | (英) Nishimura Fusanori (日) (読)
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| ○題名 (必須): | □ | (英) Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling. (日)
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| ○要約 (任意): | □ | (英) Several chemokines play important roles in recruiting the monocyte/macrophage lineage into adipose tissues. We previously found CCL19 was highly expressed in adipocytes cocultured with macrophages stimulated by endotoxin. This study aimed to evaluate the role of CCL19-CCR7 axis on obesity and insulin resistance. Serum CCL19 concentration was examined in obese model mice challenged by endotoxin. CCL19 receptor-null, Ccr7(-/-), mice and wild-type mice fed a high-fat diet or normal diet were used to investigate the role of CCL19 signals on obesity-associated inflammation. CCL19 protein was elevated in the sera of obese model mice challenged by endotoxin. Ccr7(-/-) mice were protected from diet-induced obesity and insulin resistance. The adipose tissue and liver expression of inflammatory genes of Ccr7(-/-) mice was much lower than in diet-induced obese mice. Ccr7(-/-) mice were protected from fatty liver and dyslipidemia and exhibited increased thermogenesis on high-fat feeding. CCL19 attracts activated dendritic cells (DC). The expression of the DC markers, CD11b and 11c, was not observed in the adipose tissues of Ccr7(-/-) mice fed a high-fat diet, which might be closely associated with the protection of these mice from obesity. The CCL19-CCR7 pathway associates with the development of high-fat-induced obesity and insulin resistance. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Obesity (The Obesity Society)
(pISSN: 1930-7381, eISSN: 1930-739X)
| ○ISSN (任意): | □ | 1930-739X
ISSN: 1930-7381
(pISSN: 1930-7381, eISSN: 1930-739X) Title: Obesity (Silver Spring, Md.)Title(ISO): Obesity (Silver Spring)Supplier: The Obesity SocietyPublisher: Wiley Publishing (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 23
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 1460 1471
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 7月 初日 (平成 27年 7月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/oby.21127 (→Scopusで検索)
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| ○PMID (任意): | □ | 26097021 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000356893400019
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| ○Scopus (任意): | □ | 2-s2.0-84933178175
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1002/oby.21127 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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