| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 島袋 充生
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| 2. | (英) Saito T (日) (読)
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| 3. | (英) Higa T (日) (読)
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| 4. | (英) Nakamura K (日) (読)
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| 5. | (英) Masuzaki H (日) (読)
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| 6. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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| 7. | (英) the Fukuoka diabetologists group (日) (読)
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| ○題名 (必須): | □ | (英) Risk stratification of coronary artery disease in asymptomatic diabetic subjects using multidetector computed tomography (日)
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| ○要約 (任意): | □ | (英) BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) show a greater risk for coronary artery disease (CAD), but the risk stratification in asymptomatic CAD patients has not been established. This study investigated the prevalence and severity for asymptomatic CAD and predictors in T2DM patients.METHODSANDRESULTS: In a multiclinic group, diabetic patients (320 men, 186 women) without known symptoms suggestive of CAD were recruited for multidetector computed tomography (MDCT). Patients were categorized according to severity of coronary atherosclerosis: Grade 1 (normal findings), Grade 2 (mild atherosclerosis without significant stenosis), Grade 3 (moderate stenosis/atherosclerosis, 50-74% stenosis), Grade 4 (moderate stenosis/atherosclerosis, 75-89% stenosis), Grade 5 (severe stenosis/atherosclerosis, 90% stenosis). The trend for severity grade of CAD was slightly higher in men than women (P=0.054). For critical lesions (combined Grades 3-5), the prevalence was almost equal (men 44% vs. women 37%; P=0.113). Multivariate models showed that in men, HbA1c7.4%, dyslipidemia, duration of diabetes, retinopathy, and other type of cardiovascular diseases were predictors of critical lesions and in women, duration of diabetes and retinopathy were predictors.CONCLUSIONS: The prevalence and severity of asymptomatic CAD are comparably high in men and women with T2DM. Risk stratification by using MDCT might be useful to predict asymptomatic coronary lesions requiring coronary revascularization. (Circ J 2015; 79: 2422-2429). (日)
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| ○キーワード (推奨): | 1. | (英) Coronary atherosclerosis (日) (読)
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| 2. | (英) Diabetes mellitus (日) (読)
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| 3. | (英) Multidetector computed tomography (日) (読)
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| 4. | (英) Sex difference (日) (読)
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| ○発行所 (推奨): | □ | 社団法人 日本循環器学会
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| ○誌名 (必須): | □ | Circulation Journal ([社団法人 日本循環器学会])
(pISSN: 1346-9843, eISSN: 1347-4820)
| ○ISSN (任意): | □ | 1347-4820
ISSN: 1346-9843
(pISSN: 1346-9843, eISSN: 1347-4820) Title: Circulation journal : official journal of the Japanese Circulation SocietyTitle(ISO): Circ JSupplier: 社団法人日本循環器学会Publisher: Japanese Circulation Society (NLM Catalog)
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(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 79
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| ○号 (必須): | □ | 11
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| ○頁 (必須): | □ | 2422 2429
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| ○年月日 (必須): | □ | 西暦 2015年 10月 23日 (平成 27年 10月 23日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1253/circj.CJ-15-0325 (→Scopusで検索)
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| ○PMID (任意): | □ | 26399764 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1253/circj.CJ-15-0325 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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