『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=298092EID:298092, Map:0, LastModified:2015年8月7日(金) 09:21:45, Operator:[廣島 佑香], Avail:TRUE, Censor:0, Owner:[廣島 佑香], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.廣島 佑香 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔微生物学])
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[継承]
2. (英) Hsu Kenneth (日) (読)
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[継承]
3. (英) Tedla Nicodemus (日) (読)
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[継承]
4. (英) Chung Yuen Ming (日) (読)
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[継承]
5. (英) Chow Sharron (日) (読)
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[継承]
6. (英) Herbert Cristan (日) (読)
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[継承]
7. (英) Geczy Carolyn L (日) (読)
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[継承]
題名 (必須): (英) S100A8 induces IL-10 and protects against acute lung injury.  (日)    [継承]
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要約 (任意): (英) S100A8 is considered proinflammatory by activating TLR4 and/or the receptor for advanced glycation end products. The aim was to investigate inflammatory effects of S100A8 in murine lung. S100A8 was administered to BALB/c mice by nasal inhalation and genes induced over a time-course assessed. LPS was introduced intranasally either alone or 2 h after pretreatment of mice with intranasal application of S100A8 or dexamethasone. A Cys(42)-Ala(42) mutant S100A8 mutant was used to assess whether S100A8's effects were via pathways that were dependent on reactive oxygen species. S100A8 induced IL-10 mRNA, and expression was apparent only in airway epithelial cells. Importantly, it suppressed acute lung injury provoked by LPS inhalation by suppressing mast-cell activation and induction of mediators orchestrating leukocyte recruitment, possibly by reducing NF-B activation via an IB/Akt pathway and by downmodulating pathways generating oxidative stress. The Cys(42)-Ala(42) S100A8 mutant did not induce IL-10 and was less immunosuppressive, indicating modulation by scavenging oxidants. S100A8 inhibition of LPS-mediated injury was as potent, and outcomes were remarkably similar to immunosuppression by dexamethasone. We challenge the notion that S100A8 is an agonist for TLR4 or the receptor for advanced glycation end products. S100A8 induced IL-10 in vivo and initiates a feedback loop that attenuates acute lung injury.  (日)    [継承]
キーワード (推奨): 1. (英) Acute Lung Injury (日) (読) [継承]
2. (英) Anti-Inflammatory Agents (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 192 [継承]
(必須): 6 [継承]
(必須): 2800 2811 [継承]
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年月日 (必須): 西暦 2014年 2月 14日 (平成 26年 2月 14日) [継承]
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DOI (任意): 10.4049/jimmunol.1302556    (→Scopusで検索) [継承]
PMID (任意): 24532576    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yuka Hiroshima, Kenneth Hsu, Nicodemus Tedla, Ming Yuen Chung, Sharron Chow, Cristan Herbert and L Carolyn Geczy : S100A8 induces IL-10 and protects against acute lung injury., The Journal of Immunology, Vol.192, No.6, 2800-2811, 2014.
欧文冊子 ● Yuka Hiroshima, Kenneth Hsu, Nicodemus Tedla, Ming Yuen Chung, Sharron Chow, Cristan Herbert and L Carolyn Geczy : S100A8 induces IL-10 and protects against acute lung injury., The Journal of Immunology, Vol.192, No.6, 2800-2811, 2014.

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