『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=298091EID:298091, Map:0, LastModified:2016年1月20日(水) 17:02:47, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[廣島 佑香], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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著者 (必須): 1.廣島 佑香 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔微生物学])
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2. (英) Garthwaite Linda (日) (読)
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3. (英) Hsu Kenneth (日) (読)
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4. (英) Yoo Hyouna (日) (読)
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5. (英) Park Sang-Ho (日) (読)
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6. (英) Geczy Carolyn L (日) (読)
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7. (英) Kumar Rakesh K (日) (読)
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8. (英) Herbert Cristan (日) (読)
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題名 (必須): (英) ISU201 enhances the resolution of airway inflammation in a mouse model of an acute exacerbation of asthma.  (日)    [継承]
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要約 (任意): (英) Glucocorticoids are commonly used for treating asthma and its exacerbations but have well-recognised adverse effects and are not always effective. Few alternative treatments exist. Using a murine model of an acute exacerbation of asthma, we assessed the ability of ISU201, a novel protein drug, to suppress the inflammatory response when administered after induction of an exacerbation. Sensitised mice were chronically challenged with a low mass concentration of aerosolised ovalbumin, and then received a single moderate-level challenge to simulate an allergen-induced exacerbation. ISU201 was administered to mice 2 and 8 hours later, while pulmonary inflammation and expression of mRNA for chemokines and proinflammatory cytokines were assessed after 4, 12, and 24 hours. Relative to vehicle-treated controls, ISU201 suppressed accumulation of pulmonary neutrophils and eosinophils, while accelerating the decline in CXCL1, TNF-, and IL-6 in lavage fluid and lung tissue. ISU201 significantly reduced peak expression of mRNA for the chemokines Cxcl9 and Cxcl10, the adhesion molecules Icam1 and Vcam1, and the proinflammatory cytokines Il1b, Il12p40, and Csf1. The ability of ISU201 to promote resolution of inflammation suggests that it may have potential as an alternative to glucocorticoids in the management of asthma, including when administered after the onset of an acute exacerbation.  (日)    [継承]
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誌名 (必須): Mediators of Inflammation (Hindawi Publishing Corporation)
(pISSN: 0962-9351, eISSN: 1466-1861)

ISSN (任意): 1466-1861
ISSN: 0962-9351 (pISSN: 0962-9351, eISSN: 1466-1861)
Title: Mediators of inflammation
Title(ISO): Mediators Inflamm
Publisher: Hindawi
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 2015 [継承]
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(必須): 405629 405629 [継承]
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年月日 (必須): 西暦 2015年 2月 12日 (平成 27年 2月 12日) [継承]
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DOI (任意): 10.1155/2015/405629    (→Scopusで検索) [継承]
PMID (任意): 25767333    (→Scopusで検索) [継承]
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WOS (任意): 000350161800001 [継承]
Scopus (任意): 2-s2.0-84924215816 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yuka Hiroshima, Linda Garthwaite, Kenneth Hsu, Hyouna Yoo, Sang-Ho Park, L Carolyn Geczy, K Rakesh Kumar and Cristan Herbert : ISU201 enhances the resolution of airway inflammation in a mouse model of an acute exacerbation of asthma., Mediators of Inflammation, Vol.2015, (号), 405629, 2015.
欧文冊子 ● Yuka Hiroshima, Linda Garthwaite, Kenneth Hsu, Hyouna Yoo, Sang-Ho Park, L Carolyn Geczy, K Rakesh Kumar and Cristan Herbert : ISU201 enhances the resolution of airway inflammation in a mouse model of an acute exacerbation of asthma., Mediators of Inflammation, Vol.2015, (号), 405629, 2015.

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