『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=297646EID:297646, Map:0, LastModified:2020年7月21日(火) 11:42:14, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[西岡 安彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.豊田 優子
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[継承]
2. (英) Tabata Sho (日) (読)
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[継承]
3.岸 潤
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[継承]
4. (英) Kuramoto Takuya (日) (読)
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[継承]
5. (英) Mitsuhashi Atsushi (日) (読)
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[継承]
6.西條 敦郎
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[継承]
7.河野 弘 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域リウマチ・総合内科学])
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[継承]
8.後東 久嗣
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[継承]
9.青野 純典 ([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.先端医療創生科学講座.呼吸器・膠原病内科学])
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10.埴淵 昌毅
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[継承]
11.堀川 秀昌 ([徳島大学.技術支援部.蔵本技術部門.研究開発支援グループ])
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[継承]
12. (英) Nakajima Toshihiro (日) (読)
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[継承]
13. (英) Furukawa Tatsuhiko (日) (読)
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14.曽根 三郎
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15. (英) Akiyama Shin-ichi (日) (読)
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16.西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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[継承]
題名 (必須): (英) Thymidine Phosphorylase Regulates the Expression of CXCL10 in Rheumatoid Arthritis Fibroblast-like Synoviocytes  (日)    [継承]
副題 (任意):
要約 (任意): (英) Thymidine phosphorylase (TP) in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) is induced by tumor necrosis factor α (TNFα) and other cytokines that have been reported to be major inflammation mediators in RA. We previously demonstrated that TP plays an important role in angiogenesis and tumor growth, invasion, and metastasis. The aim of this study was to investigate whether the role of TP in the pathogenesis of RA is similar to its role in tumors. In FLS obtained from 2 patients with RA, the expression of TP, interferon-γ (IFNγ)-inducible protein 10 (CXCL10), and other cytokines was measured by quantitative real-time polymerase chain reaction, immunoblotting, and enzyme-linked immunosorbent assays. Microarray analysis was performed using FLS transfected with TYMP complementary DNA and treated with a TP inhibitor. The expression of TP in FLS was up-regulated by TNFα, interleukin-1β (IL-1β), IL-17, IFNγ, and lipopolysaccharide. Microarray analysis of FLS overexpressing TP identified CXCL10 as a thymidine phosphorylase-related gene. The expression of CXCL10 was induced by TNFα, and this induction was suppressed by TYMP small interfering RNA and TP inhibitor. Furthermore, the combination of TNFα and IFNγ synergistically augmented the expression of TP and CXCL10. TP-induced CXCL10 expression was suppressed by the antioxidant EUK-8. In the synovial tissue of patients with RA, TP levels were significantly correlated with CXCL10 expression. The combination of TNFα and IFNγ strongly induced the expression of thymidine phosphorylase in RA FLS. The induction of thymidine phosphorylase enhanced the expression of CXCL10, which may contribute to the Th1 phenotype and bone destruction observed in RA.  (日)    [継承]
キーワード (推奨): 1. (英) Arthritis, Rheumatoid (日) (読) [継承]
2. (英) Cells, Cultured (日) (読) [継承]
3. (英) Chemokine CXCL10 (日) (読) [継承]
4. (英) Cytokines (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Interferon-gamma (日) (読) [継承]
7. (英) Synovial Membrane (日) (読) [継承]
8. (英) Thymidine Phosphorylase (日) (読) [継承]
9. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Arthritis & Rheumatology (American College of Rheumatology)
(pISSN: 2326-5191, eISSN: 2326-5205)

ISSN (任意): 2326-5205
ISSN: 2326-5191 (pISSN: 2326-5191, eISSN: 2326-5205)
Title: Arthritis & rheumatology (Hoboken, N.J.)
Title(ISO): Arthritis Rheumatol
Supplier: American College of Rheumatology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 66 [継承]
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(必須): 560 568 [継承]
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年月日 (必須): 西暦 2014年 3月 1日 (平成 26年 3月 1日) [継承]
URL (任意):
DOI (任意): 10.1002/art.38263    (→Scopusで検索) [継承]
PMID (任意): 24574215    (→Scopusで検索) [継承]
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WOS (任意): 000337359400011 [継承]
Scopus (任意): 2-s2.0-84896289470 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1002/art.38263  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yuko Toyoda, Sho Tabata, Jun Kishi, Takuya Kuramoto, Atsushi Mitsuhashi, Atsuro Saijo, Hiroshi Kawano, Hisatsugu Goto, Yoshinori Aono, Masaki Hanibuchi, Hideaki Horikawa, Toshihiro Nakajima, Tatsuhiko Furukawa, Saburo Sone, Shin-ichi Akiyama and Yasuhiko Nishioka : Thymidine Phosphorylase Regulates the Expression of CXCL10 in Rheumatoid Arthritis Fibroblast-like Synoviocytes, Arthritis & Rheumatology, Vol.66, No.3, 560-568, 2014.
欧文冊子 ● Yuko Toyoda, Sho Tabata, Jun Kishi, Takuya Kuramoto, Atsushi Mitsuhashi, Atsuro Saijo, Hiroshi Kawano, Hisatsugu Goto, Yoshinori Aono, Masaki Hanibuchi, Hideaki Horikawa, Toshihiro Nakajima, Tatsuhiko Furukawa, Saburo Sone, Shin-ichi Akiyama and Yasuhiko Nishioka : Thymidine Phosphorylase Regulates the Expression of CXCL10 in Rheumatoid Arthritis Fibroblast-like Synoviocytes, Arthritis & Rheumatology, Vol.66, No.3, 560-568, 2014.

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