『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=297193EID:297193, Map:0, LastModified:2016年4月18日(月) 14:45:55, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[佐田 政隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.楠瀬 賢也 ([徳島大学.病院.診療科.内科.循環器内科])
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[継承]
2.山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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[継承]
3.發知 淳子
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[継承]
4.坂東 美佳
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[継承]
5. (英) Nishio Susumu (日) (読)
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[継承]
6. (英) Hirata Yukina (日) (読)
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[継承]
7.伊勢 孝之 ([徳島大学.病院.診療科.内科.循環器内科])
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[継承]
8.山口 浩司 ([徳島大学.病院.診療科.内科.循環器内科])
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[継承]
9.八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域医療人材育成(医学域)])
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[継承]
10.添木 武 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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[継承]
11.若槻 哲三 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学]/[徳島大学.病院.診療科.内科.循環器内科])
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[継承]
12.岸 潤
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13.佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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[継承]
題名 (必須): (英) Prediction of Future Overt Pulmonary Hypertension by 6-Min Walk Stress Echocardiography in Patients With Connective Tissue Disease.  (日)    [継承]
副題 (任意):
要約 (任意): (英) BACKGROUND: Early detection of pulmonary hypertension (PH) in connective tissue disease (CTD) is crucial to ensuring that patients receive timely treatment for this progressive disease. Exercise stress tests have been used to screen patients in an attempt to identify early-stage PH. Recent studies have described abnormal mean pulmonary artery pressure (mPAP)-cardiac output (Q) responses as having the potential to assess the disease state.OBJECTIVES: This study hypothesized that pulmonary circulation pressure-flow relationships obtained by 6-min walk (6MW) stress echocardiography would better delineate differential progression of PH and predict development of PH during follow-up.METHODS: We prospectively performed 6MW stress echocardiographic studies in 78 CTD patients (age 58 ± 12 years; 9% male) at baseline and follow-up. All patients underwent yearly echocardiographic follow-up studies for up to 5 years.RESULTS: During a median period of 32 months (range: 15 to 62 months), 16 patients reached the clinical endpoint of development of PH and none died during follow-up. PH was confirmed by right heart catheterization in all 16 patients (mPAP 25 mm Hg and pulmonary capillary wedge pressure 15 mm Hg). In a Cox proportional-hazards survival model, 6MW distance (hazard ratio [HR]: 0.99; p = 0.010), early diastolic tricuspid annulus motion velocity (HR: 0.79; p = 0.025), and mPAP/Q by 6MW stress (HR: 1.10; p = 0.005) were associated with development of PH. In sequential Cox models, a model on the basis of 6MW distance (chi-square, 6.6) was improved by mPAP/Q (chi-square: 14.4; p = 0.019). Using a receiver-operating characteristic curve, we found that the best cutoff value of mPAP/Q for predicting development of pulmonary hypertension was >3.3 mm Hg/l/min.CONCLUSIONS: The 6MW stress echocardiography noninvasively provides an incremental prognostic value of PH development in CTD. This is a single-center prospective cohort study. Larger multicenter studies are warranted to confirm this result.  (日)    [継承]
キーワード (推奨): 1. (英) lupus erythematosus (日) (読) [継承]
2. (英) mixed connective tissue disease (日) (読) [継承]
3. (英) pulmonary circulation (日) (読) [継承]
4. (英) systemic scleroderma (日) (読) [継承]
発行所 (推奨): (英) American College of Cardiology Foundation (日) (読) [継承]
誌名 (必須): Journal of the American College of Cardiology (American College of Cardiology)
(pISSN: 0735-1097, eISSN: 1558-3597)

ISSN (任意): 1558-3597
ISSN: 0735-1097 (pISSN: 0735-1097, eISSN: 1558-3597)
Title: Journal of the American College of Cardiology
Title(ISO): J Am Coll Cardiol
Publisher: American College of Cardiology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 376 384 [継承]
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年月日 (必須): 西暦 2015年 7月 28日 (平成 27年 7月 28日) [継承]
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DOI (任意): 10.1016/j.jacc.2015.05.032    (→Scopusで検索) [継承]
PMID (任意): 26205595    (→Scopusで検索) [継承]
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WOS (任意): 000358600500007 [継承]
Scopus (任意): 2-s2.0-84937681606 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.jacc.2015.05.032  (日)    [継承]
2.(英) Article.ELocationID: S0735-1097(15)02477-8  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) KeywordList.Keyword: lupus erythematosus  (日)    [継承]
6.(英) KeywordList.Keyword: mixed connective tissue disease  (日)    [継承]
7.(英) KeywordList.Keyword: pulmonary circulation  (日)    [継承]
8.(英) KeywordList.Keyword: systemic scleroderma  (日)    [継承]

標準的な表示

和文冊子 ● Kenya Kusunose, Hirotsugu Yamada, Junko Hotsuchi, Mika Bando, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Jun Kishi and Masataka Sata : Prediction of Future Overt Pulmonary Hypertension by 6-Min Walk Stress Echocardiography in Patients With Connective Tissue Disease., Journal of the American College of Cardiology, Vol.66, No.4, 376-384, 2015.
欧文冊子 ● Kenya Kusunose, Hirotsugu Yamada, Junko Hotsuchi, Mika Bando, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Jun Kishi and Masataka Sata : Prediction of Future Overt Pulmonary Hypertension by 6-Min Walk Stress Echocardiography in Patients With Connective Tissue Disease., Journal of the American College of Cardiology, Vol.66, No.4, 376-384, 2015.

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