| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 元木 達夫
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| 2. | 黒部 裕嗣
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| 3. | (英) Hirata Yoichiro (日) (読)
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| 4. | (英) Nakayama Taisuke (日) (読)
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| 5. | 木下 肇
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| 6. | (英) Rocco A. Kevin (日) (読)
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| 7. | (英) Sogabe Hitoshi (日) (読)
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| 8. | 堀 隆樹
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| 9. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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| 10. | 北川 哲也
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| ○題名 (必須): | □ | (英) PPAR-gamma agonist attenuates inflammation in aortic aneurysm patients. (日)
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| ○要約 (任意): | □ | (英) Peroxisome proliferator-activated receptor (PPAR) -γ agonist, which is an anti-diabetes drug and reduces expression of tumor necrosis factor (TNF)-α, reported to have the effects for anti-inflammation in our body. In cardiovascular fields, this PPAR-γ agonist already reported to suppress progression of coronary atherosclerosis. Various cytokines, which is secreted from fat tissues around artery, promote atherosclerosis and/or aneurysmal changes in aorta/artery. Objective of our study is to clarify whether PPAR-γ agonist has anti-inflammatory effects in aorta of patients with aortic aneurysm (AA). The medical ethics committee in Tokushima University Hospital approved protocol for this study. Sixteen patients with AA (more than 5 cm in diameter, scheduled open surgery) were divided into two groups; one is PPAR-γ agonist administrating group [Formula: see text] n = 6, group P[Formula: see text], and another is the without group [Formula: see text] n = 10, group C[Formula: see text]. PPAR-γ agonist, whose dose was 15 mg/day, was administrated in the group P for more than 2 months before aneurysectomy and grafting (mean; 4.2 ± 3.4 months) (Supplemental Table 1). Biopsy specimens were obtained from abdominal subcutaneous fat, greater omentum, retroperitoneal periaortic fat and aneurysmal wall in surgical procedure. Blood examination also achieved before/after procedure. Harvested specimens were analyzed with histology (HE and EVG), immunohistochemistry (macrophage) and RT-PCR (adiponectin, MCP-1, TNF-α, CD68, matrix metalloprotease (MMP)-2, MMP-9). Macrophage infiltration in aortic wall and retroperitoneal periaortic fat among group P was significantly decreased compared to that among group C. Adiponectin expressions in both subcutaneous fat and retroperitoneal periaortic fat among the group P (adiponectin/β-actin) were significantly increased compared to those among the group C [subcutaneous fat; 16.8 ± 13.9 vs. 5.82 ± 2.94 (P = 0.04), retroperitoneal periaortic fat; 21.3 ± 24.1 vs. 2.12 ± 1.69 (P = 0.04)]. On the other hand, expressions of TNF-α, and MMP-9 in both aortic aneurysmal wall and retroperitoneal periaortic fat among group P were significantly decreased. [(Aortic aneurysmal wall; TNF-α; 0.45 ± 0.15 vs. 5.18 ± 3.49 (P = 0.02), MMP-9; 39.6 ± 69.0 vs. 721 ± 741 (P = 0.04)], [retroperitoneal periaortic fat; TNF-α; 1.14 ± 0.36 vs. 26.4 ± 25.0 (P = 0.048), MMP-9; 0.18 ± 0.21 vs. 50.0 ± 41.8 (P = 0.047)]. These data may indicate that PPAR-γ agonist become the way for preventing or delaying aortic aneurysm progression in patients. More studies will be needed to clarify this drug effects in detail. (日)
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| ○キーワード (推奨): | 1. | (英) Aortic aneurysm (日) (読)
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| 2. | 炎症 (inflammation)
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| 3. | (英) Macrophage (日) (読)
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| 4. | (英) PPAR-gamma agonist (日) (読)
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| ○発行所 (推奨): | □ | 特定非営利活動法人 日本胸部外科学会
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| ○誌名 (必須): | □ | General Thoracic and Cardiovascular Surgery ([特定非営利活動法人 日本胸部外科学会])
(pISSN: 1863-6705, eISSN: 1863-6713)
| ○ISSN (任意): | □ | 1863-6713
ISSN: 1863-6705
(pISSN: 1863-6705, eISSN: 1863-6713) Title: General thoracic and cardiovascular surgeryTitle(ISO): Gen Thorac Cardiovasc SurgPublisher: Springer (NLM Catalog)
(医中誌Web)
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(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 63
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| ○号 (必須): | □ | 10
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| ○頁 (必須): | □ | 565 571
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 10月 初日 (平成 27年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s11748-015-0576-1 (→Scopusで検索)
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| ○PMID (任意): | □ | 26213347 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-84943198660
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s11748-015-0576-1 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Aortic aneurysm (日)
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| 4. | (英) KeywordList.Keyword: Inflammation (日)
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| 5. | (英) KeywordList.Keyword: Macrophage (日)
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| 6. | (英) KeywordList.Keyword: PPAR-gamma agonist (日)
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