『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Tang Lijun (日) (読)
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2. (英) Okamoto Shiki (日) (読)
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3.志内 哲也 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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4. (英) Toda Chitoku (日) (読)
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5. (英) Takagi Kazuyo (日) (読)
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6. (英) Sato Tatsuya (日) (読)
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7. (英) Saito Kumiko (日) (読)
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8. (英) Yokota Shigefumi (日) (読)
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9. (英) Minokoshi Yasuhiko (日) (読)
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題名 (必須): (英) Sympathetic Nerve Activity Maintains an Anti-inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF- Gene Expression in Macrophages.  (日)    [継承]
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要約 (任意): (英) Adipose tissue macrophages (ATMs) play an important role in the inflammatory response in obese animals. How ATMs are regulated in lean animals has remained elusive, however. We now show that the sympathetic nervous system (SNS) is necessary to maintain the abundance of the mRNA for the proinflammatory cytokine tumor necrosis factor- (TNF-) at a low level in ATMs of lean mice. Intracerebroventricular injection of agouti related neuropeptide (AgRP) increased the amount of TNF- mRNA in epididymal (epi) white adipose tissue (WAT), but not in interscapular brown adipose tissue (BAT), through inhibition of sympathetic nerve activity in epiWAT. The surgical denervation and -adrenergic antagonist propranolol up-regulated TNF- mRNA in both epiWAT and BAT in vivo. Signaling by the 2-adrenergic receptor (2-AR) and protein kinase A (PKA) down-regulated TNF- mRNA in epiWAT explants, and suppressed lipopolysaccharide-induced up-regulation of TNF- mRNA in the stromal vascular fraction (SVF) of this tissue. -AR-deficient (-less) mice manifested an increased plasma TNF- concentration and increased TNF- mRNA abundance in epiWAT and BAT. TNF- mRNA abundance was greater in ATMs (CD11b(+) cells of the SVF) from epiWAT or BAT of wild-type mice than in corresponding CD11b(-) cells, and 2-AR mRNA abundance was greater in ATMs than in CD11b(-) cells of epiWAT. Our results show that the SNS and 2-AR-PKA pathway maintain an anti-inflammatory state in ATMs of lean mice in vivo, and that the brain melanocortin pathway plays a role in maintaining this state in WAT of lean mice via the SNS.  (日)    [継承]
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誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 156 [継承]
(必須): 10 [継承]
(必須): 3680 3694 [継承]
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年月日 (必須): 西暦 2015年 7月 1日 (平成 27年 7月 1日) [継承]
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DOI (任意): 10.1210/EN.2015-1096    (→Scopusで検索) [継承]
PMID (任意): 26132918    (→Scopusで検索) [継承]
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WOS (任意): 000362235300034 [継承]
Scopus (任意): 2-s2.0-84943638331 [継承]
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備考 (任意): 1.(英) PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● Lijun Tang, Shiki Okamoto, Tetsuya Shiuchi, Chitoku Toda, Kazuyo Takagi, Tatsuya Sato, Kumiko Saito, Shigefumi Yokota and Yasuhiko Minokoshi : Sympathetic Nerve Activity Maintains an Anti-inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF- Gene Expression in Macrophages., Endocrinology, Vol.156, No.10, 3680-3694, 2015.
欧文冊子 ● Lijun Tang, Shiki Okamoto, Tetsuya Shiuchi, Chitoku Toda, Kazuyo Takagi, Tatsuya Sato, Kumiko Saito, Shigefumi Yokota and Yasuhiko Minokoshi : Sympathetic Nerve Activity Maintains an Anti-inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF- Gene Expression in Macrophages., Endocrinology, Vol.156, No.10, 3680-3694, 2015.

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