| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 島田 健司 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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| 2. | (英) Furukawa Hajime (日) (読)
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| 3. | (英) Wada Kosuke (日) (読)
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| 4. | (英) Wei Yuan (日) (読)
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| 5. | 多田 恵曜 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| 6. | (英) Kuwabara Atsushi (日) (読)
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| 7. | (英) Shikata Fumiaki (日) (読)
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| 8. | 兼松 康久
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| 9. | (英) Lawton T. Michael (日) (読)
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| 10. | (英) Kitazato T. Keiko (日) (読)
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| 11. | 永廣 信治
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| 12. | (英) Hashimoto Tomoki (日) (読)
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| ○題名 (必須): | □ | (英) Angiotensin-(1-7) protects against the development of aneurysmal subarachnoid hemorrhage in mice (日)
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| ○要約 (任意): | □ | (英) Angiotensin-(1-7) (Ang-(1-7)) can regulate vascular inflammation and remodeling, which are processes that have important roles in the pathophysiology of intracranial aneurysms. In this study, we assessed the effects of Ang-(1-7) in the development of intracranial aneurysm rupture using a mouse model of intracranial aneurysms in which aneurysmal rupture (i.e., aneurysmal subarachnoid hemorrhage) occurs spontaneously and causes neurologic symptoms. Treatment with Ang-(1-7) (0.5 mg/kg/day), Mas receptor antagonist (A779 0.5 mg/kg/day or 2.5 mg/kg/day), or angiotensin II type 2 receptor (AT2R) antagonist (PD 123319, 10 mg/kg/day) was started 6 days after aneurysm induction and continued for 2 weeks. Angiotensin-(1-7) significantly reduced the rupture rate of intracranial aneurysms without affecting the overall incidence of aneurysms. The protective effect of Ang-(1-7) was blocked by the AT2R antagonist, but not by the Mas receptor antagonist. In AT2R knockout mice, the protective effect of Ang-(1-7) was absent. While AT2R mRNA was abundantly expressed in the cerebral arteries and aneurysms, Mas receptor mRNA expression was very scarce in these tissues. Angiotensin-(1-7) reduced the expression of tumor necrosis factor-α and interleukin-1β in cerebral arteries. These findings indicate that Ang-(1-7) can protect against the development of aneurysmal rupture in an AT2R-dependent manner. (日)
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| ○キーワード (推奨): | 1. | (英) Aneurysm, Ruptured (日) (読)
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| 2. | (英) Angiotensin I (日) (読)
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| 3. | (英) Angiotensin II (日) (読)
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| 4. | (英) Angiotensin II Type 2 Receptor Blockers (日) (読)
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| 5. | (英) Animals (日) (読)
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| 6. | 脳 (brain)
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| 7. | (英) Cerebral Arteries (日) (読)
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| 8. | 細胞質分裂 (cytokinesis)
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| 9. | (英) Imidazoles (日) (読)
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| 10. | (英) Male (日) (読)
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| 11. | (英) Mice (日) (読)
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| 12. | (英) Mice, Inbred C57BL (日) (読)
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| 13. | ノックアウトマウス (knockout mice)
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| 14. | (英) Peptide Fragments (日) (読)
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| 15. | (英) Pyridines (日) (読)
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| 16. | (英) RNA, Messenger (日) (読)
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| 17. | (英) Receptor, Angiotensin, Type 2 (日) (読)
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| 18. | (英) Subarachnoid Hemorrhage (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Cerebral Blood Flow and Metabolism (International Society of Cerebral Blood Flow and Metabolism)
(pISSN: 0271-678X, eISSN: 1559-7016)
| ○ISSN (任意): | □ | 1559-7016
ISSN: 0271-678X
(pISSN: 0271-678X, eISSN: 1559-7016) Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and MetabolismTitle(ISO): J Cereb Blood Flow MetabPublisher: SAGE Publications (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 35
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 1163 1168
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 3月 11日 (平成 27年 3月 11日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/jcbfm.2015.30 (→Scopusで検索)
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| ○PMID (任意): | □ | 25757758 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000357137500014
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| ○Scopus (任意): | □ | 2-s2.0-84934443499
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1038/jcbfm.2015.30 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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