| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Tara Shuhei (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | 黒部 裕嗣
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Rocco A. Kevin (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Maxfield W. Mark (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Best A. Cameron (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Yi Tai (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Naito Yuji (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Breuer K. Christopher (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | (英) Shinoka Toshiharu (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Well-organized neointima of large-pore poly(l-lactic acid) vascular graft coated with poly(l-lactic-co--caprolactone) prevents calcific deposition compared to small-pore electrospun poly(l-lactic acid) graft in a mouse aortic implantation model. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Tissue engineering techniques have emerged that allow bioresorbable grafts to be implanted that restore function and transform into biologically active arteries. However, these implants are susceptible to calcification during the remodeling process. The objective of this study was to evaluate the role of pore size of bioabsorbable grafts in the development of calcification. Two types of grafts were prepared: a large-pore graft constructed of poly(L-lactic acid) (PLA) fibers coated with poly(L-lactide-co-ϵ-caprolactone) (PLCL) (PLA-PLCL), and a small-pore graft made of electrospun PLA nanofibers (PLA-nano). Twenty-eight PLA-PLCL grafts and twenty-five PLA-nano grafts were implanted as infra-renal aortic interposition conduits in 8-week-old female SCID/Bg mice, and followed for 12 months after implantation. Large-pore PLA-PLCL grafts induced a well-organized neointima after 12 months, and Alizarin Red S staining showed neointimal calcification only in the thin neointima of small-pore PLA-nano grafts. At 12 months, macrophage infiltration, evaluated by F4/80 staining, was observed in the thin neointima of the PLA-nano graft, and there were few vascular smooth muscle cells (VSMCs) in this layer. On the other hand, the neointima of the PLA-PLCL graft was composed of abundant VSMCs, and a lower density of macrophages (F4/80 positive cells, PLA-PLCL; 68.1 ± 41.4/mm(2) vs PLA-nano; 188.3 ± 41.9/mm(2), p = 0.007). The VSMCs of PLA-PLCL graft expressed transcription factors of both osteoblasts and osteoclasts. These findings demonstrate that in mouse arterial circulation, large-pore PLA-PLCL grafts created a well-organized neointima and prevented calcific deposition compared to small-pore, electrospun PLA-nano grafts. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
| [継承] |
| 2. | (英) Arteries (日) (読)
| [継承] |
| 3. | (英) Calcinosis (日) (読)
| [継承] |
| 4. | コラーゲン (collagen)
| [継承] |
| 5. | (英) Elastin (日) (読)
| [継承] |
| 6. | 女性 (female)
| [継承] |
| 7. | 炎症 (inflammation)
| [継承] |
| 8. | (英) Lactic Acid (日) (読)
| [継承] |
| 9. | (英) Macrophages (日) (読)
| [継承] |
| 10. | (英) Mice (日) (読)
| [継承] |
| 11. | (英) Mice, SCID (日) (読)
| [継承] |
| 12. | (英) Microscopy, Electron, Scanning (日) (読)
| [継承] |
| 13. | (英) Models, Animal (日) (読)
| [継承] |
| 14. | (英) Neointima (日) (読)
| [継承] |
| 15. | (英) Osteoblasts (日) (読)
| [継承] |
| 16. | (英) Osteoclasts (日) (読)
| [継承] |
| 17. | (英) Osteogenesis (日) (読)
| [継承] |
| 18. | (英) Polyesters (日) (読)
| [継承] |
| 19. | (英) Polymers (日) (読)
| [継承] |
| 20. | (英) Porosity (日) (読)
| [継承] |
| 21. | 再生医学 (tissue engineering)
| [継承] |
| 22. | (英) Transcription Factors (日) (読)
| [継承] |
| 23. | (英) Vascular Grafting (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Atherosclerosis (European Atherosclerosis Society)
(pISSN: 0021-9150, eISSN: 1879-1484)
| ○ISSN (任意): | □ | 1879-1484
ISSN: 0021-9150
(pISSN: 0021-9150, eISSN: 1879-1484) Title: AtherosclerosisTitle(ISO): AtherosclerosisPublisher: Elsevier Ireland Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 237
| [継承] |
| ○号 (必須): | □ | 2
| [継承] |
| ○頁 (必須): | □ | 684 691
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2014年 10月 17日 (平成 26年 10月 17日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.atherosclerosis.2014.09.030 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 25463106 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.atherosclerosis.2014.09.030 (日)
| [継承] |
| 2. | (英) Article.ELocationID: S0021-9150(14)01439-7 (日)
| [継承] |
| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
| [継承] |
| 5. | (英) OtherID: NIHMS640781 [Available on 12/01/15] (日)
| [継承] |
| 6. | (英) OtherID: PMC4262639 [Available on 12/01/15] (日)
| [継承] |
| 7. | (英) KeywordList.Keyword: Atherosclerotic cardiovascular diseases (日)
| [継承] |
| 8. | (英) KeywordList.Keyword: Bioabsorbable grafts (日)
| [継承] |
| 9. | (英) KeywordList.Keyword: Calcification (日)
| [継承] |
| 10. | (英) KeywordList.Keyword: Electrospinning technique (日)
| [継承] |
| 11. | (英) KeywordList.Keyword: Pore size (日)
| [継承] |
| 12. | (英) KeywordList.Keyword: Tissue engineering (日)
| [継承] |