| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Stacy R. Mitchel (日) (読)
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| 2. | (英) Naito Yuji (日) (読)
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| 3. | (英) Maxfield W. Mark (日) (読)
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| 4. | 黒部 裕嗣
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| 5. | (英) Tara Shuhei (日) (読)
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| 6. | (英) Chan Chung (日) (読)
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| 7. | (英) Rocco A. Kevin (日) (読)
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| 8. | (英) Shinoka Toshiharu (日) (読)
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| 9. | (英) Sinusas J. Albert (日) (読)
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| 10. | (英) Breuer K. Christopher (日) (読)
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| ○題名 (必須): | □ | (英) Targeted imaging of matrix metalloproteinase activity in the evaluation of remodeling tissue-engineered vascular grafts implanted in a growing lamb model. (日)
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| ○要約 (任意): | □ | (英) The clinical translation of tissue-engineered vascular grafts has been demonstrated in children. The remodeling of biodegradable, cell-seeded scaffolds to functional neovessels has been partially attributed to matrix metalloproteinases. Noninvasive assessment of matrix metalloproteinase activity can indicate graft remodeling and elucidate the progression of neovessel formation. Therefore, matrix metalloproteinase activity was evaluated in grafts implanted in lambs using in vivo and ex vivo hybrid imaging. Graft growth and remodeling was quantified using in vivo x-ray computed tomography angiography. Cell-seeded and unseeded scaffolds were implanted in 5 lambs as inferior vena cava interposition grafts. At 2 and 6 months after implantation, in vivo angiography was used to assess graft morphology. In vivo and ex vivo single photon emission tomography/computed tomography imaging was performed with a radiolabeled compound targeting matrix metalloproteinase activity at 6 months. The neotissue was examined at 6 months using qualitative histologic and immunohistochemical staining and quantitative biochemical analysis. The seeded grafts demonstrated significant luminal and longitudinal growth from 2 to 6 months. In vivo imaging revealed subjectively greater matrix metalloproteinase activity in grafts versus native tissue. Ex vivo imaging confirmed a quantitative increase in matrix metalloproteinase activity and demonstrated greater activity in unseeded versus seeded grafts. The glycosaminoglycan content was increased in seeded grafts versus unseeded grafts, without significant differences in collagen content. Matrix metalloproteinase activity remained elevated in tissue-engineered grafts 6 months after implantation and could indicate remodeling. Optimization of in vivo imaging to noninvasively evaluate matrix metalloproteinase activity could assist in the serial assessment of vascular graft remodeling. (日)
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| ○キーワード (推奨): | 1. | (英) Age Factors (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Bioprosthesis (日) (読)
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| 4. | (英) Blood Vessel Prosthesis (日) (読)
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| 5. | (英) Blood Vessel Prosthesis Implantation (日) (読)
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| 6. | (英) Bone Marrow Cells (日) (読)
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| 7. | (英) Bone Marrow Transplantation (日) (読)
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| 8. | (英) Cell Proliferation (日) (読)
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| 9. | (英) Cells, Cultured (日) (読)
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| 10. | コラーゲン (collagen)
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| 11. | (英) Feasibility Studies (日) (読)
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| 12. | (英) Glycosaminoglycans (日) (読)
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| 13. | (英) Matrix Metalloproteinases (日) (読)
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| 14. | (英) Models, Animal (日) (読)
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| 15. | (英) Multidetector Computed Tomography (日) (読)
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| 16. | (英) Phlebography (日) (読)
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| 17. | (英) Prosthesis Design (日) (読)
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| 18. | (英) Sheep (日) (読)
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| 19. | (英) Time Factors (日) (読)
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| 20. | 再生医学 (tissue engineering)
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| 21. | (英) Tissue Scaffolds (日) (読)
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| 22. | (英) Tomography, Emission-Computed, Single-Photon (日) (読)
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| 23. | (英) Up-Regulation (日) (読)
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| 24. | (英) Vascular Remodeling (日) (読)
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| 25. | (英) Vena Cava, Inferior (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Thoracic and Cardiovascular Surgery (American Association for Thoracic Surgery)
(pISSN: 0022-5223, eISSN: 1097-685X)
| ○ISSN (任意): | □ | 1097-685X
ISSN: 0022-5223
(pISSN: 0022-5223, eISSN: 1097-685X) Title: The Journal of thoracic and cardiovascular surgeryTitle(ISO): J Thorac Cardiovasc SurgPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 148
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 2227 2233
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2014年 11月 初日 (平成 26年 11月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.jtcvs.2014.05.037 (→Scopusで検索)
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| ○PMID (任意): | □ | 24952823 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.jtcvs.2014.05.037 (日)
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| 2. | (英) Article.ELocationID: S0022-5223(14)00581-9 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Evaluation Studies (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 5. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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| 6. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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