| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 堤 保夫
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| 2. | 堤 理恵
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| 3. | (英) Hamaguchi Eisuke (日) (読)
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| 4. | (英) Sakai Yoko (日) (読)
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| 5. | (英) Kasai Asuka (日) (読)
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| 6. | (英) Ishikawa Yoshihiro (日) (読)
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| 7. | (英) Yokoyama Utako (日) (読)
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| 8. | (英) Tanaka Katsuya (日) (読)
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| ○題名 (必須): | □ | (英) Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3. (日)
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| ○要約 (任意): | □ | (英) We conclude that caveolae and caveolin-3 are critical for exendin-4 induced protection of the heart from ischemia/reperfusion injury. (日) Exendin-4 protected cardiac myocytes (CM) from SI/R [35.6 ± 12.6% vs. 64.4 ± 18.0% cell death, P = 0.034] and apoptosis but this protection was abolished by MβCD (71.8 ± 10.8% cell death, P = 0.004). Furthermore, Cav-3/GLP-1R co-localization was observed and membrane fractionation by sucrose density gradient centrifugation of CM treated with MβCD + exendin-4 revealed that buoyant (caveolae enriched) fractions decreased Cav-3 compared to CM treated with exendin-4 exclusively. Furthermore, exendin-4 induced a reduction in infarct size and cardiac troponin relative to control (infarct size: 25.1 ± 8.2% vs. 41.4 ± 4.1%, P < 0.001; troponin: 36.9 ± 14.2 vs. 101.1 ± 22.3 ng/ml, P < 0.001). However, exendin-4 induced cardiac protection was abolished in Cav-3 KO mice (infarct size: 43.0 ± 6.4%, P < 0.001; troponin: 96.8 ± 26.6 ng/ml, P = 0.001).
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Caveolae (日) (読)
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| 3. | (英) Caveolin 3 (日) (読)
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| 4. | (英) Hypoglycemic Agents (日) (読)
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| 5. | 虚血 (ischemia)
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| 6. | (英) Male (日) (読)
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| 7. | (英) Mice, Inbred C57BL (日) (読)
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| 8. | ノックアウトマウス (knockout mice)
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| 9. | (英) Myocardial Reperfusion Injury (日) (読)
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| 10. | 心筋 (myocardium)
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| 11. | (英) Myocytes, Cardiac (日) (読)
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| 12. | (英) Peptides (日) (読)
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| 13. | (英) Rats, Wistar (日) (読)
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| 14. | (英) Venoms (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cardiovascular Diabetology ([BioMed Central Ltd.])
(eISSN: 1475-2840)
| ○ISSN (任意): | □ | 1475-2840
ISSN: 1475-2840
(eISSN: 1475-2840) Title: Cardiovascular diabetologyTitle(ISO): Cardiovasc DiabetolPublisher: BioMed Central (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 13
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 132 132
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2014年 9月 7日 (平成 26年 9月 7日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1186/s12933-014-0132-9 (→Scopusで検索)
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| ○PMID (任意): | □ | 25194961 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS : | □ | 000345359900001
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| ○Scopus (任意): | 1. | 2-s2.0-84964812082
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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