『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Kozuka Chisayo (日) (読)
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[継承]
2. (英) Sunagawa Sumito (日) (読)
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[継承]
3. (英) Ueda Rei (日) (読)
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[継承]
4. (英) Higa Moritake (日) (読)
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[継承]
5. (英) Tanaka Hideaki (日) (読)
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[継承]
6. (英) Shimizu-Okabe Chigusa (日) (読)
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7. (英) Ishiuchi Shogo (日) (読)
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[継承]
8. (英) Takayama Chitoshi (日) (読)
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9. (英) Matsushita Masayuki (日) (読)
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10. (英) Tsutsui Masato (日) (読)
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[継承]
11. (英) Miyazaki Masato (日) (読)
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12.親泊 政一 ([徳島大学.先端酵素学研究所.重点研究部門])
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13.島袋 充生
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14. (英) Masuzaki Hiroaki (日) (読)
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題名 (必須): (英) Gamma-oryzanol protects pancreatic -cells against endoplasmic reticulum stress in male mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Endoplasmic reticulum (ER) stress is profoundly involved in dysfunction of β-cells under high-fat diet and hyperglycemia. Our recent study in mice showed that γ-oryzanol, a unique component of brown rice, acts as a chemical chaperone in the hypothalamus and improves feeding behavior and diet-induced dysmetabolism. However, the entire mechanism whereby γ-oryzanol improves glucose metabolism throughout the body still remains unclear. In this context, we tested whether γ-oryzanol reduces ER stress and improves function and survival of pancreatic β-cells using murine β-cell line MIN6. In MIN6 cells with augmented ER stress by tunicamycin, γ-oryzanol decreased exaggerated expression of ER stress-related genes and phosphorylation of eukaryotic initiation factor-2α, resulting in restoration of glucose-stimulated insulin secretion and prevention of apoptosis. In islets from high-fat diet-fed diabetic mice, oral administration of γ-oryzanol improved glucose-stimulated insulin secretion on following reduction of exaggerated ER stress and apoptosis. Furthermore, we examined the impact of γ-oryzanol on low-dose streptozotocin-induced diabetic mice, where exaggerated ER stress and resultant apoptosis in β-cells were observed. Also in this model, γ-oryzanol attenuated mRNA level of genes involved in ER stress and apoptotic signaling in islets, leading to amelioration of glucose dysmetabolism. Taken together, our findings demonstrate that γ-oryzanol directly ameliorates ER stress-induced β-cell dysfunction and subsequent apoptosis, highlighting usefulness of γ-oryzanol for the treatment of diabetes mellitus.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2.アポトーシス (apoptosis) [継承]
3. (英) Cell Line (日) (読) [継承]
4. (英) Cell Survival (日) (読) [継承]
5. (英) Diabetes Mellitus, Experimental (日) (読) [継承]
6. (英) Diet, High-Fat (日) (読) [継承]
7. (英) Endoplasmic Reticulum Stress (日) (読) [継承]
8.インスリン (insulin) [継承]
9. (英) Insulin-Secreting Cells (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Phenylpropionates (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 156 [継承]
(必須): 4 [継承]
(必須): 1242 1250 [継承]
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年月日 (必須): 西暦 2015年 4月 初日 (平成 27年 4月 初日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2014-1748    (→Scopusで検索) [継承]
PMID (任意): 25594697    (→Scopusで検索) [継承]
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WOS (任意): 000353272700006 [継承]
Scopus (任意): 2-s2.0-84926429654 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1210/en.2014-1748  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Chisayo Kozuka, Sumito Sunagawa, Rei Ueda, Moritake Higa, Hideaki Tanaka, Chigusa Shimizu-Okabe, Shogo Ishiuchi, Chitoshi Takayama, Masayuki Matsushita, Masato Tsutsui, Masato Miyazaki, Seiichi Oyadomari, Michio Shimabukuro and Hiroaki Masuzaki : Gamma-oryzanol protects pancreatic -cells against endoplasmic reticulum stress in male mice., Endocrinology, Vol.156, No.4, 1242-1250, 2015.
欧文冊子 ● Chisayo Kozuka, Sumito Sunagawa, Rei Ueda, Moritake Higa, Hideaki Tanaka, Chigusa Shimizu-Okabe, Shogo Ishiuchi, Chitoshi Takayama, Masayuki Matsushita, Masato Tsutsui, Masato Miyazaki, Seiichi Oyadomari, Michio Shimabukuro and Hiroaki Masuzaki : Gamma-oryzanol protects pancreatic -cells against endoplasmic reticulum stress in male mice., Endocrinology, Vol.156, No.4, 1242-1250, 2015.

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