『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=294872EID:294872, Map:0, LastModified:2016年1月15日(金) 16:43:54, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[宮本 洋二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1.永井 宏和
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[継承]
2.小林 真左子
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[継承]
3.藤澤 健司
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[継承]
4.大江 剛 ([徳島大学.病院.診療科.歯科口腔外科.口腔外科])
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[継承]
5.髙丸 菜都美
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[継承]
6. (英) Hara Kanae (日) (読)
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[継承]
7.内田 大亮
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[継承]
8.玉谷 哲也
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学籍番号 (推奨):
[継承]
9. (英) Ishikawa Kunio (日) (読)
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学籍番号 (推奨):
[継承]
10.宮本 洋二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Effects of low crystalline carbonate apatite on proliferation and osteoblastic differentiation of human bone marrow cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) Carbonated apatite (CO3Ap) is the inorganic component of bone. We have proposed a new method for the fabrication of CO3Ap blocks based on a dissolution-precipitation method using a synthetic precursor. The aim of this study is to examine the effects of low crystalline CO3Ap on initial cell attachment, proliferation and osteoblastic differentiation of human bone marrow cells (hBMCs) using sintered hydroxyapatite and tissue culture plates as controls. Initial cell attachment and proliferation were assessed with a MTT assay. Expression of osteoblastic markers was examined by reverse transcription-polymerase chain reaction. XRD and FT-IR results showed formation of B-type carbonate apatite with lower crystallinity. No difference was observed for initial cell attachment between HAp and CO3Ap discs. hBMSC attached more significantly on tissue culture plate than on HAp and CO3Ap discs. The number of cells on HAp was higher than that on CO3Ap until day 7, after which the number of cells was similar. hBMSC proliferated more significantly on tissue culture plate than on HAp and CO3Ap discs. In contrast, hBMCs incubated on CO3Ap demonstrated much higher expression of osteoblastic markers of differentiation, such as type I collagen, alkaline phosphatase, osteopontin and osteocalcin, than hBMCs on HAp. On the tissue culture plate, they were not any change throughout the culture period. These results demonstrated that low crystalline CO3Ap exhibit higher osteoinductivity than HAp.  (日)    [継承]
キーワード (推奨): 1. (英) Alkaline Phosphatase (日) (読) [継承]
2. (英) Apatites (日) (読) [継承]
3. (英) Biomarkers (日) (読) [継承]
4. (英) Bone Marrow Cells (日) (読) [継承]
5. (英) Bone Substitutes (日) (読) [継承]
6. (英) Cell Adhesion (日) (読) [継承]
7. (英) Cell Culture Techniques (日) (読) [継承]
8.細胞分化 (cell differentiation) [継承]
9. (英) Cell Proliferation (日) (読) [継承]
10. (英) Collagen Type I (日) (読) [継承]
11.結晶化 (crystallization) [継承]
12. (英) Durapatite (日) (読) [継承]
13. (英) Humans (日) (読) [継承]
14. (英) Materials Testing (日) (読) [継承]
15. (英) Osteoblasts (日) (読) [継承]
16. (英) Osteocalcin (日) (読) [継承]
17. (英) Osteogenesis (日) (読) [継承]
18.オステオポンティン (osteopontin) [継承]
19. (英) Spectroscopy, Fourier Transform Infrared (日) (読) [継承]
20.X線回折 (X-ray diffraction) [継承]
発行所 (推奨):
誌名 (必須): Journal of Materials Science. Materials in Medicine (European Society for Biomaterials)
(pISSN: 0957-4530, eISSN: 1573-4838)

ISSN (任意): 1573-4838
ISSN: 0957-4530 (pISSN: 0957-4530, eISSN: 1573-4838)
Title: Journal of materials science. Materials in medicine
Title(ISO): J Mater Sci Mater Med
Supplier: Kluwer Online
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 26 [継承]
(必須): 2 [継承]
(必須): 99 99 [継承]
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年月日 (必須): 西暦 2015年 2月 6日 (平成 27年 2月 6日) [継承]
URL (任意):
DOI (任意): 10.1007/s10856-015-5431-5    (→Scopusで検索) [継承]
PMID (任意): 25655499    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000349402400038 [継承]
Scopus (任意): 2-s2.0-84922324403 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1007/s10856-015-5431-5  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hirokazu Nagai, Masako Fujioka-Kobayashi, Kenji Fujisawa, Go Ohe, Natsumi Takamaru, Kanae Hara, Daisuke Uchida, Tetsuya Tamatani, Kunio Ishikawa and Youji Miyamoto : Effects of low crystalline carbonate apatite on proliferation and osteoblastic differentiation of human bone marrow cells, Journal of Materials Science. Materials in Medicine, Vol.26, No.2, 99, 2015.
欧文冊子 ● Hirokazu Nagai, Masako Fujioka-Kobayashi, Kenji Fujisawa, Go Ohe, Natsumi Takamaru, Kanae Hara, Daisuke Uchida, Tetsuya Tamatani, Kunio Ishikawa and Youji Miyamoto : Effects of low crystalline carbonate apatite on proliferation and osteoblastic differentiation of human bone marrow cells, Journal of Materials Science. Materials in Medicine, Vol.26, No.2, 99, 2015.

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