| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 池田 康将 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学]/[徳島大学.医学部.医学科.病態情報医学講座.薬理学分野]/[徳島大学.医学研究科.医学専攻.病態情報医学講座]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学])
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| 2. | (英) Hamano Hirofumi (日) 濱野 裕章 (読) はまの ひろふみ
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 3. | (英) Satoh Akiho (日) 佐藤 明穂 (読) さとう あきほ
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| ○学籍番号 (推奨): | □ | ****
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| 4. | 堀ノ内 裕也
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| 5. | 石澤 有紀 (->個人[井澤 有紀])
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| 6. | 木平 孝高
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| 7. | 石澤 啓介 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床薬理学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 8. | 粟飯原 賢一 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| ○学籍番号 (推奨): |
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| 9. | 土屋 浩一郎 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学]/[徳島大学.医学部.医学科.病態情報医学講座])
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| ○学籍番号 (推奨): |
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| 10. | 玉置 俊晃
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| ○題名 (必須): | □ | (英) Bilirubin exerts pro-angiogenic effects through an Akt-eNOS-dependent pathway (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Low serum bilirubin levels are associated with the risk of cardiovascular diseases including peripheral artery disease. Bilirubin is known to exert its property such as antioxidant effect or the enhancement of flow-mediated vasodilation, however, bilirubin action on angiogenesis remains unclear. To investigate the molecular mechanism of bilirubin on angiogenic effect, we first employed C57BL/6J mice with unilateral hindlimb ischemia surgery and divided the mice into two groups (vehicle-treated group and bilirubin-treated group). The analysis of laser speckle blood flow demonstrated the enhancement of blood flow recovery in response to ischemia of mice with bilirubin treatment. The density of capillaries was significantly higher in ischemic-adductor muscles of bilirubin-treated mice. The phosphorylated levels of endothelial nitric oxide synthase (eNOS) and Akt were increased in ischemic skeletal muscles of mice with bilirubin treatment compared with vehicle treatment. In in vitro experiments by using human aortic endothelial cells, bilirubin augmented eNOS and Akt phosphorylation, cell proliferation, cell migration and tube formation. These bilirubin actions on endothelial cell activation were inhibited by LY294002, a phosphatidylinositol 3-kinase inhibitor. In conclusion, bilirubin promotes angiogenesis through endothelial cells activation via Akt-eNOS-dependent manner. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Hypertension Research (日本高血圧学会)
(pISSN: 0916-9636, eISSN: 1348-4214)
| ○ISSN (任意): | □ | 1348-4214
ISSN: 0916-9636
(pISSN: 0916-9636, eISSN: 1348-4214) Title: Hypertension research : official journal of the Japanese Society of HypertensionTitle(ISO): Hypertens ResSupplier: 日本高血圧学会Publisher: Springer Nature (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 38
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| ○号 (必須): | □ | 11
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| ○頁 (必須): | □ | 733 740
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 7月 2日 (平成 27年 7月 2日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/hr.2015.74 (→Scopusで検索)
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| ○PMID (任意): | □ | 26134126 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000364584100006
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| ○Scopus (任意): | □ | 2-s2.0-84946558014
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1038/hr.2015.74 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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