『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Liao James (日) (読)
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[継承]
2. (英) Azelmat Jabrane (日) (読)
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[継承]
3. (英) Zhao Lei (日) (読)
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学籍番号 (推奨):
[継承]
4.吉岡 昌美
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学籍番号 (推奨):
[継承]
5.日野出 大輔 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健衛生学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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学籍番号 (推奨):
[継承]
6. (英) Grenier Daniel (日) (読)
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[継承]
題名 (必須): (英) The Kampo medicine Rokumigan possesses antibiofilm, anti-inflammatory, and wound healing properties.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Periodontal diseases, which are inflammatory diseases of bacterial origin affecting the tooth-supporting tissues, are characterized by inflammation and destruction of gingival connective tissue and alveolar bone, and may lead to tooth loss. The aim of the study was to investigate Rokumigan, a Kampo Japanese traditional medicine made of six different plants, for its capacity to prevent biofilm formation by Fusobacterium nucleatum, to inhibit interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion by mucosal cells, and to promote wound healing in a fibroblast model. Using a microplate colorimetric assay, Rokumigan prevented biofilm formation by F. nucleatum, while it had no effect on bacterial growth. Rokumigan inhibited IL-6 secretion in both epithelial cells and fibroblasts stimulated with lipopolysaccharide. However, it caused no significant inhibition of IL-8 secretion by both cell types. Rokumigan significantly increased proliferation and migration of gingival fibroblasts in a wound healing assay. In conclusion, the Kampo formulation Rokumigan, through suppression of biofilm formation by F. nucleatum, inhibition of IL-6 secretion by gingival epithelial cells and fibroblasts, and promotion of wound healing in a fibroblast model, may have potential application for periodontal diseases.  (日)    [継承]
キーワード (推奨): 1. (英) Anti-Inflammatory Agents (日) (読) [継承]
2. (英) Biofilms (日) (読) [継承]
3. (英) Cell Line (日) (読) [継承]
4. (英) Drugs, Chinese Herbal (日) (読) [継承]
5. (英) Epithelial Cells (日) (読) [継承]
6. (英) Fibroblasts (日) (読) [継承]
7. (英) Fusobacterium nucleatum (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Interleukin-6 (日) (読) [継承]
10. (英) Interleukin-8 (日) (読) [継承]
11. (英) Medicine, Kampo (日) (読) [継承]
12. (英) Wound Healing (日) (読) [継承]
発行所 (推奨):
誌名 (必須): BioMed Research International (Hindawi Pub. Co.)
(pISSN: 2314-6133, eISSN: 2314-6141)

ISSN (任意): 2314-6141
ISSN: 2314-6133 (pISSN: 2314-6133, eISSN: 2314-6141)
Title: BioMed research international
Title(ISO): Biomed Res Int
Publisher: Hindawi
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 2014 [継承]
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(必須): 436206 436206 [継承]
都市 (任意):
年月日 (必須): 西暦 2014年 4月 30日 (平成 26年 4月 30日) [継承]
URL (任意):
DOI (任意): 10.1155/2014/436206    (→Scopusで検索) [継承]
PMID (任意): 24877093    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84901255883 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● James Liao, Jabrane Azelmat, Lei Zhao, Masami Yoshioka, Daisuke Hinode and Daniel Grenier : The Kampo medicine Rokumigan possesses antibiofilm, anti-inflammatory, and wound healing properties., BioMed Research International, Vol.2014, (号), 436206, 2014.
欧文冊子 ● James Liao, Jabrane Azelmat, Lei Zhao, Masami Yoshioka, Daisuke Hinode and Daniel Grenier : The Kampo medicine Rokumigan possesses antibiofilm, anti-inflammatory, and wound healing properties., BioMed Research International, Vol.2014, (号), 436206, 2014.

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