| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kohno Shohei (日) (読)
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| ○学籍番号 (推奨): |
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| 2. | (英) Ueji Tatsuya (日) (読)
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| 3. | 安倍 知紀
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| 4. | (英) Nakao Reiko (日) (読)
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| 5. | 平坂 勝也
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| ○学籍番号 (推奨): |
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| 6. | (英) Oarada Motoko (日) (読)
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| 7. | 原田 晃子
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| [継承] |
| 8. | 真板 綾子
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | (英) Higashibata Akira (日) (読)
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| 10. | 向井 理恵 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野])
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| ○貢献度 (任意): |
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| 11. | 寺尾 純二
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| ○貢献度 (任意): |
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| [継承] |
| 12. | 奥村 裕司
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| ○学籍番号 (推奨): |
| [継承] |
| 13. | 二川 健 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Rantes secreted from macrophages disturbs skeletal muscle regeneration after cardiotoxin injection in Cbl-b-deficient mice (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Deficiency of the Cbl-b ubiquitin ligase gene activates macrophages in mice. This study aimed to elucidate the pathophysiological roles of macrophages in muscle degeneration/regeneration in Cbl-b-deficient mice. We examined immune cell infiltration and cytokine expression in cardiotoxin-injected tibialis anterior muscle of Cbl-b-deficient mice. Ablation of the Cbl-b gene expression delayed regeneration of cardiotoxin-induced skeletal muscle damage compared with wild-type mice. CD8-positive T cells were still present in the damaged muscle on day 14 after cardiotoxin injection in Cbl-b-deficient mice, but there was dispersal of the same cells over that time-frame in wild-type mice. Infiltrating macrophages in Cbl-b-deficient mice showed strong expression of RANTES (regulated-on-activation, normal T cell expressed and secreted), a chemokine for CD8-positive T cells. In turn, a neutralizing antibody against RANTES significantly suppressed the infiltration of CD8-positive T cells into the muscle, resulting in restoration of the disturbed muscle regeneration. Cbl-b is an important regulatory factor for cytotoxic T-cell infiltration via RANTES production in macrophages. (日)
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| ○キーワード (推奨): | 1. | (英) Adaptor Proteins, Signal Transducing (日) (読)
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| 2. | 分散分析 (analysis of variance)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Antibodies (日) (読)
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| 5. | (英) Antigens, CD (日) (読)
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| 6. | (英) Cardiotoxins (日) (読)
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| 7. | (英) Chemokine CCL5 (日) (読)
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| 8. | 細胞質分裂 (cytokinesis)
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| 9. | (英) Disease Models, Animal (日) (読)
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| 10. | (英) Dose-Response Relationship, Drug (日) (読)
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| 11. | (英) Gene Expression Regulation (日) (読)
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| 12. | (英) Macrophages (日) (読)
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| 13. | (英) Mice (日) (読)
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| 14. | (英) Mice, Inbred C57BL (日) (読)
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| 15. | ノックアウトマウス (knockout mice)
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| 16. | (英) Muscle, Skeletal (日) (読)
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| 17. | (英) Muscular Diseases (日) (読)
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| 18. | (英) Myogenic Regulatory Factors (日) (読)
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| 19. | (英) Proto-Oncogene Proteins c-cbl (日) (読)
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| 20. | (英) RNA, Messenger (日) (読)
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| 21. | 再生 (regeneration)
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| 22. | (英) Time Factors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Muscle & Nerve (American Association of Electromyography and Electrodiagnosis/American Association of Electrodiagnostic Medicine)
(pISSN: 0148-639X, eISSN: 1097-4598)
| ○ISSN (任意): | □ | 1097-4598
ISSN: 0148-639X
(pISSN: 0148-639X, eISSN: 1097-4598) Title: Muscle & nerveTitle(ISO): Muscle NerveSupplier: American Association of Neuromuscular & Electrodiagnostic MedicinePublisher: Wiley (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 43
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 223 229
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 2月 初日 (平成 23年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/mus.21829 (→Scopusで検索)
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| ○PMID (任意): | □ | 21254087 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000286558300012
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| ○Scopus (任意): | □ | 2-s2.0-78751674465
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1002/mus.21829 (日)
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| 2. | (英) Article.Affiliation: Department of Nutritional Physiology, Institute of Health Biosciences, University of Tokushima, Tokushima, Japan. (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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