| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Rajapakse Sanath (日) (読)
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| 2. | (英) Ogiwara Katsueki (日) (読)
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| 3. | 山野 範子
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| 4. | (英) Kimura Atsushi (日) (読)
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| 5. | (英) Hirata Kensaku (日) (読)
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| 6. | (英) Takahashi Sumio (日) (読)
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| 7. | (英) Takahashi Takayuki (日) (読)
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| ○題名 (必須): | □ | (英) Characterization of mouse tissue kallikrein 5 (日)
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| ○要約 (任意): | □ | (英) Mouse tissue kallikreins (Klks) are members of a large, multigene family consisting of 37 genes, 26 of which can code for functional proteins. Mouse tissue kallikrein 5 (Klk5) has long been thought to be one of these functional genes, but the gene product, mK5, has not been isolated and characterized. In the present study, we prepared active recombinant mK5 using an Escherichia coli expression system, followed by column chromatography. We then determined the biochemical and enzymatic properties of purified mK5. mK5 had trypsin-like activity for Arg at the P1 position, and its activity was inhibited by typical serine protease inhibitors. mK5 degraded gelatin, fibronectin, collagen type IV, high-molecular-weight kininogen, and insulin-like growth factor binding protein-3. Our data suggest that mK5 may be implicated in the process of extracellular matrix remodeling. (日)
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| ○キーワード (推奨): | 1. | (英) Amino Acid Sequence (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | 大腸菌 (Escherichia coli)
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| 4. | 遺伝子発現 (gene expression)
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| 5. | (英) Kallikreins (日) (読)
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| 6. | (英) Mice (日) (読)
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| 7. | (英) Recombinant Proteins (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Zoological Science ([社団法人 日本動物学会])
(pISSN: 0289-0003, eISSN: 2212-3830)
| ○ISSN (任意): | □ | 0289-0003
ISSN: 0289-0003
(pISSN: 0289-0003, eISSN: 2212-3830) Title: Zoological scienceTitle(ISO): Zoolog SciSupplier: 社団法人日本動物学会Publisher: Zoological Society of Japan (NLM Catalog)
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| ○巻 (必須): | □ | 23
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| ○号 (必須): | □ | 11
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| ○頁 (必須): | □ | 963 968
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2006年 11月 初日 (平成 18年 11月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2108/zsj.23.963 (→Scopusで検索)
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| ○PMID (任意): | □ | 17189908 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-33846496677
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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