『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=291148EID:291148, Map:0, LastModified:2017年11月29日(水) 17:45:15, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[金子 一郎], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Segawa Hiroko (日) (読)
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[継承]
2. (英) Onitsuka Akemi (日) (読)
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[継承]
3. (英) Furutani Junya (日) (読)
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[継承]
4.金子 一郎 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.応用栄養学])
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[継承]
5. (英) Aranami Fumito (日) (読)
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[継承]
6. (英) Matsumoto Natsuki (日) (読)
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[継承]
7. (英) Tomoe Yuka (日) (読)
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[継承]
8. (英) Kuwahata Masashi (日) (読)
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[継承]
9. (英) Ito Mikiko (日) (読)
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10.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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11. (英) Li Minqi (日) (読)
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12. (英) Amizuka Norio (日) (読)
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13. (英) Miyamoto Ken-ichi (日) (読)
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[継承]
題名 (必須): (英) Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development  (日)    [継承]
副題 (任意):
要約 (任意): (英) Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a rare autosomal recessively inherited disorder, characterized by hypophosphatemia, short stature, rickets and/or osteomalacia, and secondary absorptive hypercalciuria. HHRH is caused by a defect in the sodium-dependent phosphate transporter (NaPi-IIc/Npt2c/NPT2c), which was thought to have only a minor role in renal phosphate (P(i)) reabsorption in adult mice. In fact, mice that are null for Npt2c (Npt2c(-/-)) show no evidence for renal phosphate wasting when maintained on a diet with a normal phosphate content. To obtain insights and the relative importance of Npt2a and Npt2c, we now studied Npt2a(-/-)Npt2c(+/+), Npt2a(+/-)Npt2c(-/-), and Npt2a(-/-)Npt2c(-/-) double-knockout (DKO). DKO mice exhibited severe hypophosphatemia, hypercalciuria, and rickets. These findings are different from those in Npt2a KO mice that show only a mild phosphate and bone phenotype that improve over time and from the findings in Npt2c KO mice that show no apparent abnormality in the regulation of phosphate homeostasis. Because of the nonredundant roles of Npt2a and Npt2c, DKO animals showed a more pronounced reduction in P(i) transport activity in the brush-border membrane of renal tubular cells than that in the mice with the single-gene ablations. A high-P(i) diet after weaning rescued plasma phosphate levels and the bone phenotype in DKO mice. Our findings thus showed in mice that Npt2a and Npt2c have independent roles in the regulation of plasma P(i) and bone mineralization.  (日)    [継承]
キーワード (推奨): 1.加齢 (aging/->キーワード[老化]) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Bone and Bones (日) (読) [継承]
4. (英) Calcification, Physiologic (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Genotype (日) (読) [継承]
7.ホメオスタシス (homeostasis) [継承]
8. (英) Hypercalciuria (日) (読) [継承]
9. (英) Hypophosphatemic Rickets, X-Linked Dominant (日) (読) [継承]
10. (英) Kidney Calculi (日) (読) [継承]
11. (英) Kidney Tubules (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Mice (日) (読) [継承]
14. (英) Mice, Inbred C57BL (日) (読) [継承]
15. (英) Mice, Knockout (日) (読) [継承]
16. (英) Microvilli (日) (読) [継承]
17. (英) Phenotype (日) (読) [継承]
18. (英) Phosphates (日) (読) [継承]
19. (英) Phosphorus, Dietary (日) (読) [継承]
20. (英) Sodium-Phosphate Cotransporter Proteins, Type IIa (日) (読) [継承]
21. (英) Sodium-Phosphate Cotransporter Proteins, Type IIc (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Physiology, Renal Physiology ([アメリカ生理学会])
(pISSN: 1931-857X, eISSN: 1522-1466)

ISSN (任意): 1522-1466
ISSN: 1931-857X (pISSN: 1931-857X, eISSN: 1522-1466)
Title: American journal of physiology. Renal physiology
Title(ISO): Am J Physiol Renal Physiol
Publisher: American Physiological Society
 (NLM Catalog  (Scopus  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 297 [継承]
(必須): 3 [継承]
(必須): F671 678 [継承]
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年月日 (必須): 西暦 2009年 7月 1日 (平成 21年 7月 1日) [継承]
URL (任意):
DOI (任意): 10.1152/ajprenal.00156.2009    (→Scopusで検索) [継承]
PMID (任意): 19570882    (→Scopusで検索) [継承]
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WOS (任意): 000270269900015 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Dept. of Molecular Nutrition Institution of Health Bioscience, The Univ. of Tokushima Graduate School Kuramoto-Cho 3, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hiroko Segawa, Akemi Onitsuka, Junya Furutani, Ichiro Kaneko, Fumito Aranami, Natsuki Matsumoto, Yuka Tomoe, Masashi Kuwahata, Mikiko Ito, Mitsuru Matsumoto, Minqi Li, Norio Amizuka and Ken-ichi Miyamoto : Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development, American Journal of Physiology, Renal Physiology, Vol.297, No.3, F671-678, 2009.
欧文冊子 ● Hiroko Segawa, Akemi Onitsuka, Junya Furutani, Ichiro Kaneko, Fumito Aranami, Natsuki Matsumoto, Yuka Tomoe, Masashi Kuwahata, Mikiko Ito, Mitsuru Matsumoto, Minqi Li, Norio Amizuka and Ken-ichi Miyamoto : Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development, American Journal of Physiology, Renal Physiology, Vol.297, No.3, F671-678, 2009.

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