『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=291059EID:291059, Map:0, LastModified:2015年3月3日(火) 22:24:50, Operator:[山田 久嗣], Avail:TRUE, Censor:0, Owner:[山田 久嗣], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.山田 久嗣 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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2. (英) Tanabe Kazuhito (日) (読)
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3. (英) Nishimoto Sei-Ichi (日) (読)
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題名 (必須): (英) Site-selective strand cleavage at methylated cytosine: regional effect of naphthoquinone chromophore on the one-electron photooxidation of 5-methylcytosine and positive charge transfer in DNA.  (日)    [継承]
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要約 (任意): (英) Photoirradiation and subsequent hot piperidine treatment of the duplex consisting of 5-methylcytosine ((m)C)-containing DNA and 2-methyl-1,4-naphthoquinone (NQ)-tethered complementary ODN led to oxidative strand cleavage selectively at the (m)C site, when the NQ was arranged so as to be in close contact with the target (m)C. Well designed incorporation of NQ into an interior of ODN could suppress a competitive strand cleavage at consecutive guanines, which occurred as a result of positive charge transfer. In contrast to the ODNs bearing NQ in an interior of the strand, photoirradiation of the duplex with an NQ tethered to a flexible methylene linker at the strand end resulted in not only strong strand cleavage at (m)C but also small amount of strand cleavage at the G doublet. Thus, optimization of the regional position of photosensitizing NQ could provide exclusive strand cleavage at (m)C without unfavorable cleavage at G.  (日)    [継承]
キーワード (推奨): 1. (英) 5-Methylcytosine (日) (読) [継承]
2. (英) DNA (日) (読) [継承]
3. (英) DNA Methylation (日) (読) [継承]
4. (英) Electrons (日) (読) [継承]
5. (英) Genes, p53 (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Oligodeoxyribonucleotides (日) (読) [継承]
8. (英) Oxidation-Reduction (日) (読) [継承]
9. (英) Photosensitizing Agents (日) (読) [継承]
10. (英) Sequence Analysis, DNA (日) (読) [継承]
11. (英) Vitamin K 3 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Nucleic Acids Symposium Series (Symposium on Nucleic Acids Chemistry)
(pISSN: 0261-3166, eISSN: 1746-8272)

ISSN (任意): 1746-8272
ISSN: 0261-3166 (pISSN: 0261-3166, eISSN: 1746-8272)
Title: Nucleic acids symposium series
Title(ISO): Nucleic Acids Symp Ser
Publisher: Oxford University Press
 (NLM Catalog  (NLM Catalog  (Scopus  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2007年 0月 初日 (平成 19年 0月 初日) [継承]
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DOI (任意): 10.1093/nass/nrm110    (→Scopusで検索) [継承]
PMID (任意): 18029665    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hisatsugu Yamada, Kazuhito Tanabe and Sei-Ichi Nishimoto : Site-selective strand cleavage at methylated cytosine: regional effect of naphthoquinone chromophore on the one-electron photooxidation of 5-methylcytosine and positive charge transfer in DNA., Nucleic Acids Symposium Series, No.51, 219-220, 2007.
欧文冊子 ● Hisatsugu Yamada, Kazuhito Tanabe and Sei-Ichi Nishimoto : Site-selective strand cleavage at methylated cytosine: regional effect of naphthoquinone chromophore on the one-electron photooxidation of 5-methylcytosine and positive charge transfer in DNA., Nucleic Acids Symposium Series, No.51, 219-220, 2007.

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