『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=291054EID:291054, Map:0, LastModified:2016年3月25日(金) 15:30:50, Operator:[三好 小文], Avail:TRUE, Censor:0, Owner:[山田 久嗣], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ito Takeo (日) (読)
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2. (英) Tanabe Kazuhito (日) (読)
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3.山田 久嗣 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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学籍番号 (推奨):
[継承]
4. (英) Hatta Hiroshi (日) (読)
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5. (英) Nishimoto Sei-ichi (日) (読)
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題名 (必須): (英) Radiation- and photo-induced activation of 5-fluorouracil prodrugs as a strategy for the selective treatment of solid tumors.  (日)    [継承]
副題 (任意):
要約 (任意): (英) 5-Fluorouracil (5-FU) is used widely as an anticancer drug to treat solid cancers, such as colon, breast, rectal, and pancreatic cancers, although its clinical application is limited because 5-FU has gastrointestinal and hematological toxicity. Many groups are searching for prodrugs with functions that are tumor selective in their delivery and can be activated to improve the clinical utility of 5-FU as an important cancer chemotherapeutic agent. UV and ionizing radiation can cause chemical reactions in a localized area of the body, and these have been applied in the development of site-specific drug activation and sensitization. In this review, we describe recent progress in the development of novel 5-FU prodrugs that are activated site specifically by UV light and ionizing radiation in the tumor microenvironment. We also discuss the chemical mechanisms underlying this activation.  (日)    [継承]
キーワード (推奨): 1. (英) Drug Delivery Systems (日) (読) [継承]
2. (英) Fluorouracil (日) (読) [継承]
3. (英) Humans (日) (読) [継承]
4. (英) Neoplasms (日) (読) [継承]
5. (英) Prodrugs (日) (読) [継承]
6. (英) Radiation, Ionizing (日) (読) [継承]
7. (英) Ultraviolet Rays (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecules (Molecular Diversity Preservation International)
(eISSN: 1420-3049)

ISSN (任意): 1420-3049
ISSN: 1420-3049 (pISSN: 1433-1373, eISSN: 1420-3049)
Title: Molecules (Basel, Switzerland)
Title(ISO): Molecules
Supplier: Springer Online Journal Archive
Publisher: Springer Science+Business Media
 (NLM Catalog  (Scopus  (CrossRef  (CrossRef (Scopus information is found. [need login])
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(必須): 13 [継承]
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(必須): 2370 2384 [継承]
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年月日 (必須): 西暦 2008年 10月 1日 (平成 20年 10月 1日) [継承]
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DOI (任意): 10.3390/molecules13102370    (→Scopusで検索) [継承]
PMID (任意): 18830160    (→Scopusで検索) [継承]
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WOS (任意): 000260505100002 [継承]
Scopus (任意): 2-s2.0-55249084962 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Review  (日)    [継承]

標準的な表示

和文冊子 ● Takeo Ito, Kazuhito Tanabe, Hisatsugu Yamada, Hiroshi Hatta and Sei-ichi Nishimoto : Radiation- and photo-induced activation of 5-fluorouracil prodrugs as a strategy for the selective treatment of solid tumors., Molecules, Vol.13, No.10, 2370-2384, Oct. 2008.
欧文冊子 ● Takeo Ito, Kazuhito Tanabe, Hisatsugu Yamada, Hiroshi Hatta and Sei-ichi Nishimoto : Radiation- and photo-induced activation of 5-fluorouracil prodrugs as a strategy for the selective treatment of solid tumors., Molecules, Vol.13, No.10, 2370-2384, Oct. 2008.

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