『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=291053EID:291053, Map:0, LastModified:2015年3月3日(火) 21:46:06, Operator:[山田 久嗣], Avail:TRUE, Censor:0, Owner:[山田 久嗣], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.山田 久嗣 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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2. (英) Tanabe Kazuhito (日) (読)
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[継承]
3. (英) Ito Takeo (日) (読)
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4. (英) Nishimoto Sei-Ichi (日) (読)
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題名 (必須): (英) The pH effect on the naphthoquinone-photosensitized oxidation of 5-methylcytosine.  (日)    [継承]
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要約 (任意): (英) The pH effect on the one-electron photooxidation of 5-methyl-2'-deoxycytidine (d(m)C) by sensitization with 2-methyl-1,4-naphthoquinone (NQ) was investigated. Photoirradiation of an aqueous solution containing d(m)C and NQ under slightly acidic conditions of pH 5.0 efficiently produced 5-formyl-2'-deoxycytidine, whereas similar NQ-photosensitized oxidation of d(m)C proceeded to a lesser extent under more acidic or basic conditions. Fluorescence-quenching experiments revealed that the less-efficient photooxidation at pH values below 4.5 is attributed to the decreased rate of one-electron oxidation of d(m)C owing to protonation at the N(3)-position. The NQ-photosensitized oxidation of an N(4)-dimethyl-substituted d(m)C derivative under various pH conditions also suggests that the pH change in the range of 5.0 to 8.0 may be responsible for a reversible deprotonation-protonation equilibrium at the N(4)-exocyclic amino group of the d(m)C radical cation. In accord with the photochemical reactivity of monomeric d(m)C, the 5-methylcytosine residue in oligodeoxynucleotides was oxidized efficiently by photoexcited NQ-tethered oligodeoxynucleotides under slightly acidic conditions to form an alkali-labile 5-formylcytosine residue.  (日)    [継承]
キーワード (推奨): 1. (英) 5-Methylcytosine (日) (読) [継承]
2. (英) Chromatography, High Pressure Liquid (日) (読) [継承]
3. (英) Hydrogen-Ion Concentration (日) (読) [継承]
4. (英) Molecular Structure (日) (読) [継承]
5. (英) Naphthoquinones (日) (読) [継承]
6. (英) Oxidation-Reduction (日) (読) [継承]
7. (英) Photosensitizing Agents (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Chemistry - A European Journal ([Wiley-VCH])
(pISSN: 0947-6539, eISSN: 1521-3765)

ISSN (任意): 1521-3765
ISSN: 0947-6539 (pISSN: 0947-6539, eISSN: 1521-3765)
Title: Chemistry (Weinheim an der Bergstrasse, Germany)
Title(ISO): Chemistry
Supplier: Chemistry Europe
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 14 [継承]
(必須): 33 [継承]
(必須): 10453 10461 [継承]
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年月日 (必須): 西暦 2008年 0月 初日 (平成 20年 0月 初日) [継承]
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DOI (任意): 10.1002/chem.200800840    (→Scopusで検索) [継承]
PMID (任意): 18830980    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hisatsugu Yamada, Kazuhito Tanabe, Takeo Ito and Sei-Ichi Nishimoto : The pH effect on the naphthoquinone-photosensitized oxidation of 5-methylcytosine., Chemistry - A European Journal, Vol.14, No.33, 10453-10461, 2008.
欧文冊子 ● Hisatsugu Yamada, Kazuhito Tanabe, Takeo Ito and Sei-Ichi Nishimoto : The pH effect on the naphthoquinone-photosensitized oxidation of 5-methylcytosine., Chemistry - A European Journal, Vol.14, No.33, 10453-10461, 2008.

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