『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=291047EID:291047, Map:0, LastModified:2015年3月3日(火) 21:23:32, Operator:[山田 久嗣], Avail:TRUE, Censor:0, Owner:[山田 久嗣], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Tanabe Kazuhito (日) (読)
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[継承]
2. (英) Harada Hiroshi (日) (読)
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[継承]
3. (英) Narazaki Michiko (日) (読)
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[継承]
4. (英) Tanaka Kazuo (日) (読)
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[継承]
5. (英) Inafuku Kenichi (日) (読)
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[継承]
6. (英) Komatsu Hirokazu (日) (読)
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[継承]
7. (英) Ito Takeo (日) (読)
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8.山田 久嗣 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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9. (英) Chujo Yoshiki (日) (読)
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10. (英) Matsuda Tetsuya (日) (読)
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11. (英) Hiraoka Masahiro (日) (読)
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12. (英) Nishimoto Sei-ichi (日) (読)
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題名 (必須): (英) Monitoring of biological one-electron reduction by (19)F NMR using hypoxia selective activation of an (19)F-labeled indolequinone derivative.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Biological reduction of fluorine-labeled indolequinone derivative (IQ-F) was characterized by (19)F NMR for quantitative molecular understanding. The chemical shift change in (19)F NMR allowed monitoring of the enzymatic reduction of IQ-F. Upon hypoxic treatment of IQ-F with NADPH:cytochrome P450 reductase, IQ-F was activated via catalytic one-electron reduction to release nonafluoro-tert-butyl alcohol (F-OH), while the formation of F-OH was significantly suppressed under aerobic conditions. Similar hypoxia-selective reduction of IQ-F occurred within A549 cells, which expresses NADPH:cytochrome P450 reductase. The kinetic analysis was also performed to propose a reaction mechanism. The molecular oxygen slightly prevents the binding of IQ-F to reductase, while the rate of net reaction was decreased due to oxidation of a semiquinone anion radical intermediate generated by one-electron reduction of IQ-F. The disappearance of IQ-F and appearance of F-OH were imaged by (19)F fast spin echo, thus visualizing the hypoxia-selective reduction of IQ-F by means of MR imaging.  (日)    [継承]
キーワード (推奨): 1. (英) Anoxia (日) (読) [継承]
2. (英) Cell Line (日) (読) [継承]
3. (英) Fluorine Radioisotopes (日) (読) [継承]
4. (英) Humans (日) (読) [継承]
5. (英) Indolequinones (日) (読) [継承]
6. (英) Magnetic Resonance Spectroscopy (日) (読) [継承]
7. (英) Oxidation-Reduction (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of the American Chemical Society ([アメリカ化学会])
(pISSN: 0002-7863, eISSN: 1520-5126)

ISSN (任意): 1520-5126
ISSN: 0002-7863 (pISSN: 0002-7863, eISSN: 1520-5126)
Title: Journal of the American Chemical Society
Title(ISO): J. Am. Chem. Soc.
Publisher: American Chemical Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 131 [継承]
(必須): 44 [継承]
(必須): 15982 15983 [継承]
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年月日 (必須): 西暦 2009年 11月 11日 (平成 21年 11月 11日) [継承]
URL (任意):
DOI (任意): 10.1021/ja904953b    (→Scopusで検索) [継承]
PMID (任意): 19842623    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kazuhito Tanabe, Hiroshi Harada, Michiko Narazaki, Kazuo Tanaka, Kenichi Inafuku, Hirokazu Komatsu, Takeo Ito, Hisatsugu Yamada, Yoshiki Chujo, Tetsuya Matsuda, Masahiro Hiraoka and Sei-ichi Nishimoto : Monitoring of biological one-electron reduction by (19)F NMR using hypoxia selective activation of an (19)F-labeled indolequinone derivative., Journal of the American Chemical Society, Vol.131, No.44, 15982-15983, 2009.
欧文冊子 ● Kazuhito Tanabe, Hiroshi Harada, Michiko Narazaki, Kazuo Tanaka, Kenichi Inafuku, Hirokazu Komatsu, Takeo Ito, Hisatsugu Yamada, Yoshiki Chujo, Tetsuya Matsuda, Masahiro Hiraoka and Sei-ichi Nishimoto : Monitoring of biological one-electron reduction by (19)F NMR using hypoxia selective activation of an (19)F-labeled indolequinone derivative., Journal of the American Chemical Society, Vol.131, No.44, 15982-15983, 2009.

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