『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=291044)

EID=291044EID:291044, Map:0, LastModified:2015年3月3日(火) 20:45:25, Operator:[山田 久嗣], Avail:TRUE, Censor:0, Owner:[山田 久嗣], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.山田 久嗣 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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2. (英) Kurata Masayuki (日) (読)
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[継承]
3. (英) Tanabe Kazuhito (日) (読)
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[継承]
4. (英) Ito Takeo (日) (読)
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5. (英) Nishimoto Sei-ichi (日) (読)
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題名 (必須): (英) Synthesis and photooxidation of oligodeoxynucleotides containing 5-dimethylaminocytosine as an efficient hole-trapping site in the positive-charge transfer through DNA duplexes.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have designed and synthesized DNA duplexes containing 5-dimethylaminocytosine ((DMA)C) to investigate the effects of C(5)-substituted cytosine bases on the transfer and trapping of positive charge (holes) in DNA duplexes. Fluorescence quenching experiments revealed that a (DMA)C base is more readily one-electron oxidized into a radical cation intermediate as compared with other natural nucleobases. Upon photoirradiation of the duplexes containing (DMA)C, the photosensitizer-injected hole migrated through the DNA bases and was trapped efficiently at the (DMA)C sites, where an enhanced oxidative strand cleavage occurred by hot piperidine treatment. The (DMA)C radical cation formed by hole transfer may undergo specific hydration and subsequent addition of molecular oxygen, thereby leading to its decomposition followed by a predominant strand cleavage at the (DMA)C site. This remarkable property suggests that the modified cytosine (DMA)C can function as an efficient hole-trapping site in the positive-charge transfer in DNA duplexes.  (日)    [継承]
キーワード (推奨): 1. (英) Base Sequence (日) (読) [継承]
2. (英) Cytosine (日) (読) [継承]
3. (英) DNA (日) (読) [継承]
4. (英) Electrons (日) (読) [継承]
5. (英) Nucleic Acid Conformation (日) (読) [継承]
6. (英) Oligodeoxyribonucleotides (日) (読) [継承]
7. (英) Oxidation-Reduction (日) (読) [継承]
8. (英) Photochemical Processes (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Organic & Biomolecular Chemistry ([英国王立化学会])
(pISSN: 1477-0520, eISSN: 1477-0539)

ISSN (任意): 1477-0539
ISSN: 1477-0520 (pISSN: 1477-0520, eISSN: 1477-0539)
Title: Organic & biomolecular chemistry
Title(ISO): Org Biomol Chem
Publisher: Royal Society of Chemistry
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 10 [継承]
(必須): 10 [継承]
(必須): 2035 2043 [継承]
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年月日 (必須): 西暦 2012年 1月 25日 (平成 24年 1月 25日) [継承]
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DOI (任意): 10.1039/c2ob06642d    (→Scopusで検索) [継承]
PMID (任意): 22273807    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hisatsugu Yamada, Masayuki Kurata, Kazuhito Tanabe, Takeo Ito and Sei-ichi Nishimoto : Synthesis and photooxidation of oligodeoxynucleotides containing 5-dimethylaminocytosine as an efficient hole-trapping site in the positive-charge transfer through DNA duplexes., Organic & Biomolecular Chemistry, Vol.10, No.10, 2035-2043, 2012.
欧文冊子 ● Hisatsugu Yamada, Masayuki Kurata, Kazuhito Tanabe, Takeo Ito and Sei-ichi Nishimoto : Synthesis and photooxidation of oligodeoxynucleotides containing 5-dimethylaminocytosine as an efficient hole-trapping site in the positive-charge transfer through DNA duplexes., Organic & Biomolecular Chemistry, Vol.10, No.10, 2035-2043, 2012.

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