『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Komatsu Hirokazu (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Yoshihara Kazuki (日) (読)
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学籍番号 (推奨):
[継承]
3.山田 久嗣 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Kimura Yu (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Son Aoi (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Nishimoto Sei-ichi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Tanabe Kazuhito (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Ruthenium complexes with hydrophobic ligands that are key factors for the optical imaging of physiological hypoxia.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The phosphorescence emission of ruthenium complexes was applied to the optical imaging of physiological hypoxia. We prepared three complexes with hydrophobic substituents on the phenanthroline ligand and characterized their emission, which was quenched by molecular oxygen. Among the complexes synthesized in this study, a pyrene chromophore-linked ruthenium complex, Ru-Py, exhibited optimal properties for the imaging of hypoxia; the prolonged lifetime of the triplet excited state of the ruthenium chromophore, which was induced by efficient energy distribution and transfer from the pyrene unit, provided the highest sensitivity towards molecular oxygen. The introduction of hydrophobic pyrene increased the lipophilicity of the complex, leading to enhanced cellular uptake. Consequently, the bright phosphorescence of Ru-Py was seen in the cytoplasm of viable hypoxic cells, whereas the signal from aerobic cells was markedly weaker. Thus, we could clearly discriminate between hypoxic and aerobic cells by monitoring the phosphorescence emission. Furthermore, Ru-Py was applied to optical imaging in live mice. An intramuscular injection of Ru-Py successfully visualized ischemia-based hypoxia, which was constructed by leg banding.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Anoxia (日) (読) [継承]
3. (英) Coordination Complexes (日) (読) [継承]
4. (英) Hydrophobic and Hydrophilic Interactions (日) (読) [継承]
5. (英) Ligands (日) (読) [継承]
6. (英) Luminescent Measurements (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Molecular Structure (日) (読) [継承]
9. (英) Optical Imaging (日) (読) [継承]
10. (英) Phenanthrolines (日) (読) [継承]
11. (英) Photochemistry (日) (読) [継承]
12. (英) Pyrenes (日) (読) [継承]
13. (英) Pyridines (日) (読) [継承]
14. (英) Ruthenium (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Chemistry - A European Journal ([Wiley-VCH])
(pISSN: 0947-6539, eISSN: 1521-3765)

ISSN (任意): 1521-3765
ISSN: 0947-6539 (pISSN: 0947-6539, eISSN: 1521-3765)
Title: Chemistry (Weinheim an der Bergstrasse, Germany)
Title(ISO): Chemistry
Supplier: Chemistry Europe
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
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(必須): 19 [継承]
(必須): 6 [継承]
(必須): 1971 1977 [継承]
都市 (任意):
年月日 (必須): 西暦 2012年 12月 20日 (平成 24年 12月 20日) [継承]
URL (任意):
DOI (任意): 10.1002/chem.201202809    (→Scopusで検索) [継承]
PMID (任意): 23281056    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hirokazu Komatsu, Kazuki Yoshihara, Hisatsugu Yamada, Yu Kimura, Aoi Son, Sei-ichi Nishimoto and Kazuhito Tanabe : Ruthenium complexes with hydrophobic ligands that are key factors for the optical imaging of physiological hypoxia., Chemistry - A European Journal, Vol.19, No.6, 1971-1977, 2012.
欧文冊子 ● Hirokazu Komatsu, Kazuki Yoshihara, Hisatsugu Yamada, Yu Kimura, Aoi Son, Sei-ichi Nishimoto and Kazuhito Tanabe : Ruthenium complexes with hydrophobic ligands that are key factors for the optical imaging of physiological hypoxia., Chemistry - A European Journal, Vol.19, No.6, 1971-1977, 2012.

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