『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=291041EID:291041, Map:0, LastModified:2016年1月22日(金) 10:34:16, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[山田 久嗣], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.山田 久嗣 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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2. (英) Hasegawa Yoshinori (日) (読)
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3. (英) Imai Hirohiko (日) (読)
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4. (英) Takayama Yuki (日) (読)
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5. (英) Sugihara Fuminori (日) (読)
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6. (英) Matsuda Tetsuya (日) (読)
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7. (英) Tochio Hidehito (日) (読)
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8. (英) Shirakawa Masahiro (日) (読)
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9. (英) Sando Shinsuke (日) (読)
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10. (英) Kimura Yu (日) (読)
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11. (英) Toshimitsu Akio (日) (読)
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12. (英) Aoyama Yasuhiro (日) (読)
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13. (英) Kondo Teruyuki (日) (読)
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題名 (必須): (英) Magnetic resonance imaging of tumor with a self-traceable phosphorylcholine polymer.  (日)    [継承]
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要約 (任意): (英)   (日) Polymers are concentration-amplified with respect to the monomeric units. We show here that a phosphorylcholine polymer enriched with (13)C/(15)N at the methyl groups is self-traceable by multiple-resonance (heteronuclear-correlation) NMR in tumor-bearing mice inoculated with the mouse rectal cancer cell line (colon 26). Preliminary measurements indicated that the present polymeric nanoprobe was satisfactorily distinguished from lipids and detectable with far sub-micromolar spectroscopic and far sub-millimolar imaging sensitivities. Detailed ex vivo and in vivo studies for the tumor-bearing mice administered the probe with a mean molecular weight of 63 000 and a mean size of 13 nm, revealed the following: (1) this probe accumulates in the tumor highly selectively (besides renal excretion) and efficiently (up to 30% of the injected dose), (2) the tumor can thus be clearly in vivo imaged, the lowest clearly imageable dose of the probe being 100 mg/kg or 2.0 mg/20-g mouse, and (3) the competition between renal excretion and tumor accumulation is size-controlled; that is, the larger (higher molecular-weight) and smaller (lower molecular-weight) portions of the probe undergo tumor accumulation and renal excretion, respectively. The observed size dependence suggests that the efficient tumor-targeting of the present probe is stimulated primarily by the so-called enhanced permeability and retention (EPR) effect, that is, size-allowed invasion of the probe into the tumor tissue via defective vascular wall. Self-traceable polymers thus open an important area of magnetic resonance imaging (MRI) of tumors and may provide a highly potential tool to visualize various delivery/localization processes using synthetic polymers.   [継承]
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誌名 (必須): Journal of the American Chemical Society ([アメリカ化学会])
(pISSN: 0002-7863, eISSN: 1520-5126)

ISSN (任意): 1520-5126
ISSN: 0002-7863 (pISSN: 0002-7863, eISSN: 1520-5126)
Title: Journal of the American Chemical Society
Title(ISO): J Am Chem Soc
Publisher: American Chemical Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 137 [継承]
(必須): 2 [継承]
(必須): 799 806 [継承]
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年月日 (必須): 西暦 2015年 1月 6日 (平成 27年 1月 6日) [継承]
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DOI (任意): 10.1021/ja510479v    (→Scopusで検索) [継承]
PMID (任意): 25560796    (→Scopusで検索) [継承]
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WOS (任意): 000348483400045 [継承]
Scopus (任意): 2-s2.0-84921451995 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hisatsugu Yamada, Yoshinori Hasegawa, Hirohiko Imai, Yuki Takayama, Fuminori Sugihara, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, Shinsuke Sando, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama and Teruyuki Kondo : Magnetic resonance imaging of tumor with a self-traceable phosphorylcholine polymer., Journal of the American Chemical Society, Vol.137, No.2, 799-806, 2015.
欧文冊子 ● Hisatsugu Yamada, Yoshinori Hasegawa, Hirohiko Imai, Yuki Takayama, Fuminori Sugihara, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, Shinsuke Sando, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama and Teruyuki Kondo : Magnetic resonance imaging of tumor with a self-traceable phosphorylcholine polymer., Journal of the American Chemical Society, Vol.137, No.2, 799-806, 2015.

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