『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.足立 隼
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2. (英) Murakawa Yasuhiro (日) (読)
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3. (英) Hiraga Sota (日) (読)
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題名 (必須): (英) Dynamic nature of SecA and its associated proteins in Escherichia coli.  (日)    [継承]
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要約 (任意): (英) Mechanical properties such as physical constraint and pushing of chromosomes are thought to be important for chromosome segregation in Escherichia coli and it could be mediated by a hypothetical molecular "tether." However, the actual tether that mediates these features is not known. We previously described that SecA (Secretory A) and Secretory Y (SecY), components of the membrane protein translocation machinery, and AcpP (Acyl carrier protein P) were involved in chromosome segregation and homeostasis of DNA topology. In the present work, we performed three-dimensional deconvolution of microscopic images and time-lapse experiments of these proteins together with MukB and DNA topoisomerases, and found that these proteins embraced the structures of tortuous nucleoids with condensed regions. Notably, SecA, SecY, and AcpP dynamically localized in cells, which was interdependent on each other requiring the ATPase activity of SecA. Our findings imply that the membrane protein translocation machinery plays a role in the maintenance of proper chromosome partitioning, possibly through "tethering" of MukB [a functional homolog of structural maintenance of chromosomes (SMC) proteins], DNA gyrase, DNA topoisomerase IV, and SeqA (Sequestration A).  (日)    [継承]
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誌名 (必須): Frontiers in Microbiology (Frontiers Media S.A.)
(eISSN: 1664-302X)

ISSN (任意): 1664-302X
ISSN: 1664-302X (eISSN: 1664-302X)
Title: Frontiers in microbiology
Title(ISO): Front Microbiol
Publisher: Frontiers Media S.A.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2015年 2月 10日 (平成 27年 2月 10日) [継承]
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DOI (任意): 10.3389/fmicb.2015.00075    (→Scopusで検索) [継承]
PMID (任意): 25713567    (→Scopusで検索) [継承]
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WOS (任意): 000350212000001 [継承]
Scopus (任意): 2-s2.0-84927523846 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

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和文冊子 ● Shun Adachi, Yasuhiro Murakawa and Sota Hiraga : Dynamic nature of SecA and its associated proteins in Escherichia coli., Frontiers in Microbiology, Vol.6, No.75, 1-12, 2015.
欧文冊子 ● Shun Adachi, Yasuhiro Murakawa and Sota Hiraga : Dynamic nature of SecA and its associated proteins in Escherichia coli., Frontiers in Microbiology, Vol.6, No.75, 1-12, 2015.

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