| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学 (2015年4月1日〜)
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| 2. | 徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学 (2015年4月1日〜)
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| ○著者 (必須): | 1. | 岩浅 亮彦 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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| 2. | 新垣 理恵子
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| 3. | (英) Honma Naoko (日) (読)
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| 4. | (英) Ushio Aya (日) (読)
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| 5. | 山田 安希子
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| 6. | (英) Kondo Tomoyuki (日) (読)
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| 7. | (英) Kurosawa Emi (日) (読)
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| 8. | (英) Kujiraoka Satoko (日) (読)
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| 9. | (英) Tsunematsu Takaaki (日) (読)
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| 10. | 工藤 保誠 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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| 11. | 田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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| 12. | (英) Yoshimura Noriko (日) (読)
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| 13. | (英) Harada Nobuhiro (日) (読)
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| 14. | 林 良夫
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| 15. | 石丸 直澄 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| ○題名 (必須): | □ | (英) Aromatase controls Sjögren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages. (日)
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| ○要約 (任意): | □ | (英) Several autoimmune diseases are known to develop in postmenopausal women. However, the mechanism by which estrogen deficiency influences autoimmunity is unknown. Aromatase is an enzyme that converts androgens to estrogens. Herein, we used female aromatase gene knockout (ArKO) mice as a model of estrogen deficiency to investigate the molecular mechanism that underlies the onset and development of autoimmunity. Histological analyses showed that inflammatory lesions in the lacrimal and salivary glands of ArKO mice increased with age. Adoptive transfer of spleen cells or bone marrow cells from ArKO mice into recombination activating gene 2 knockout mice failed to induce the autoimmune lesions. Expression of mRNA encoding proinflammatory cytokines and monocyte chemotactic protein-1 increased in white adipose tissue of ArKO mice and was significantly higher than that in wild-type mice. Moreover, an increased number of inflammatory M1 macrophages was observed in white adipose tissue of ArKO mice. A significantly increased monocyte chemotactic protein-1 mRNA expression of the salivary gland tissue in ArKO was found together with adiposity. Furthermore, the autoimmune lesions in a murine model of Sjögren syndrome were exacerbated by administration of an aromatase inhibitor. These results suggest that aromatase may play a key role in the pathogenesis of Sjögren syndrome-like lesions by controlling the target organ and adipose tissue-associated macrophage. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The American Journal of Pathology ([American Society for Investigative Pathology])
(pISSN: 0002-9440, eISSN: 1525-2191)
| ○ISSN (任意): | □ | 1525-2191
ISSN: 0002-9440
(pISSN: 0002-9440, eISSN: 1525-2191) Title: The American journal of pathologyTitle(ISO): Am J PatholPublisher: American Society for Investigative Pathology (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 185
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 151 161
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 1月 初日 (平成 27年 1月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.ajpath.2014.09.006 (→Scopusで検索)
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| ○PMID (任意): | □ | 25447050 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000346887200014
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| ○Scopus (任意): | □ | 2-s2.0-84918779178
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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