| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 足立 隼
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| ○学籍番号 (推奨): |
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| 2. | (英) Hori Kotaro (日) (読)
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| 3. | (英) Hiraga Sota (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Subcellular positioning of F plasmid mediated by dynamic localization of SopA and SopB. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) SopA, SopB proteins and the cis-acting sopC DNA region of F plasmid are essential for partitioning of the plasmid, ensuring proper subcellular positioning of the plasmid DNA molecules. We have analyzed by immunofluorescence microscopy the subcellular localization of SopA and SopB. The majority of SopB molecules formed foci, which localized frequently with F plasmid DNA molecules. The foci increased in number in proportion to the cell length. Interestingly, beside the foci formation, SopB formed a spiral structure that was dependent on SopA, which also formed a spiral structure, independent of the presence of SopB, and these two structures partially overlapped. On the basis of these results and previous biochemical studies together with our simulations, we propose a theoretical model named "the reaction-diffusion partitioning model", using reaction-diffusion equations that explain the dynamic subcellular localization of SopA and SopB proteins and the subcellular positioning of F plasmid. We hypothesized that sister copies of plasmid DNA compete with each other for sites at which SopB multimer is at the optimum concentration. The plasmid incompatibility mediated by the Sop system might be explained clearly by this hypothesis. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Bacterial Proteins (日) (読)
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| 3. | 大腸菌 (Escherichia coli)
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| 4. | (英) Escherichia coli Proteins (日) (読)
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| 5. | (英) F Factor (日) (読)
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| 6. | 免疫組織化学 (immunohistochemistry)
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| 7. | 数学 (mathematics)
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| 8. | (英) Models, Theoretical (日) (読)
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| 9. | (英) Recombinant Fusion Proteins (日) (読)
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| 10. | (英) Subcellular Fractions (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Molecular Biology (Elsevier Ltd.)
(pISSN: 0022-2836, eISSN: 1089-8638)
| ○ISSN (任意): | □ | 0022-2836
ISSN: 0022-2836
(pISSN: 0022-2836, eISSN: 1089-8638) Title: Journal of molecular biologyTitle(ISO): J Mol BiolPublisher: Academic Press (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 356
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 850 863
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2005年 12月 20日 (平成 17年 12月 20日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.jmb.2005.11.088 (→Scopusで検索)
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| ○PMID (任意): | □ | 16403518 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000235254500002
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| ○Scopus (任意): | □ | 2-s2.0-31344431592
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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