『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.足立 隼
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2. (英) Murakawa Yasuhiro (日) (読)
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3. (英) Hiraga Sota (日) (読)
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題名 (必須): (英) SecA defects are accompanied by dysregulation of MukB, DNA gyrase, chromosome partitioning and DNA superhelicity in Escherichia coli.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Spatial regulation of nucleoids and chromosome-partitioning proteins is important for proper chromosome partitioning in Escherichia coli. However, the underlying molecular mechanisms are unknown. In the present work, we showed that mutation or chemical perturbation of secretory A (SecA), an ATPase component of the membrane protein translocation machinery, SecY, a component of the membrane protein translocation channel and acyl carrier protein P (AcpP), which binds to SecA and MukB, a functional homologue of structural maintenance of chromosomes protein (SMC), resulted in a defect in chromosome partitioning. We further showed that SecA is essential for proper positioning of the oriC DNA region, decatenation and maintenance of superhelicity of DNA. Genetic interaction studies revealed that the topological abnormality observed in the secA mutant was due to combined inhibitory effects of defects in MukB, DNA gyrase and Topo IV, suggesting a role for the membrane protein translocation machinery in chromosome partitioning and/or structural maintenance of chromosomes.  (日)    [継承]
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誌名 (必須): Microbiology ([Society for General Microbiology])
(pISSN: 1350-0872, eISSN: 1465-2080)

ISSN (任意): 1465-2080
ISSN: 1350-0872 (pISSN: 1350-0872, eISSN: 1465-2080)
Title: Microbiology (Reading, England)
Title(ISO): Microbiology (Reading)
Publisher: Microbiology Society [PENDING]
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 160 [継承]
(必須): Pt 8 [継承]
(必須): 1648 1658 [継承]
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年月日 (必須): 西暦 2014年 5月 23日 (平成 26年 5月 23日) [継承]
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DOI (任意): 10.1099/mic.0.077685-0    (→Scopusで検索) [継承]
PMID (任意): 24858081    (→Scopusで検索) [継承]
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WOS (任意): 000341678900009 [継承]
Scopus (任意): 2-s2.0-84905270651 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shun Adachi, Yasuhiro Murakawa and Sota Hiraga : SecA defects are accompanied by dysregulation of MukB, DNA gyrase, chromosome partitioning and DNA superhelicity in Escherichia coli., Microbiology, Vol.160, No.Pt 8, 1648-1658, 2014.
欧文冊子 ● Shun Adachi, Yasuhiro Murakawa and Sota Hiraga : SecA defects are accompanied by dysregulation of MukB, DNA gyrase, chromosome partitioning and DNA superhelicity in Escherichia coli., Microbiology, Vol.160, No.Pt 8, 1648-1658, 2014.

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