『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=288586EID:288586, Map:0, LastModified:2014年12月8日(月) 10:00:29, Operator:[親泊 政一], Avail:TRUE, Censor:0, Owner:[親泊 政一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨):
著者 (必須): 1. (英) Azuma Yoshinori (日) (読)
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[継承]
2. (英) Hagiwara Daisuke (日) (読)
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3. (英) Lu Wenjun (日) (読)
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4. (英) Morishita Yoshiaki (日) (読)
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5. (英) Suga Hidetaka (日) (読)
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6. (英) Goto Motomitsu (日) (読)
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7. (英) Banno Ryoichi (日) (読)
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8. (英) Sugimura Yoshihisa (日) (読)
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9.親泊 政一 ([徳島大学.先端酵素学研究所.重点研究部門])
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10. (英) Mori Kazutoshi (日) (読)
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11. (英) Shiota Akira (日) (読)
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12. (英) Asai Naoya (日) (読)
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13. (英) Takahashi Masahide (日) (読)
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14. (英) Oiso Yutaka (日) (読)
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15. (英) Arima Hiroshi (日) (読)
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題名 (必須): (英) Activating transcription factor 6 is required for the vasopressin neuron system to maintain water balance under dehydration in male mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Activating transcription factor 6 (ATF6) is a sensor of endoplasmic reticulum (ER) stress and increases the expression of ER chaperones and molecules related to the ER-associated degradation of unfolded/misfolded proteins. In this study, we used ATF6 knockout (ATF6(-/-)) mice to clarify the role of ATF6 in the arginine vasopressin (AVP) neuron system. Although urine volumes were not different between ATF6(-/-) and wild-type (ATF6(+/+)) mice with access to water ad libitum, they were increased in ATF6(-/-) mice compared with those in ATF6(+/+) mice under intermittent water deprivation (WD) and accompanied by less urine AVP in ATF6(-/-) mice. The mRNA expression of immunoglobulin heavy chain binding protein, an ER chaperone, was significantly increased in the supraoptic nucleus in ATF6(+/+) but not ATF6(-/-) mice after WD. Electron microscopic analyses demonstrated that the ER lumen of AVP neurons was more dilated in ATF6(-/-) mice than in ATF6(+/+) mice after WD. ATF6(-/-) mice that were mated with mice possessing a mutation causing familial neurohypophysial diabetes insipidus (FNDI), which is characterized by progressive polyuria and AVP neuronal loss due to the accumulation of mutant AVP precursor in the ER, manifested increased urine volume under intermittent WD. The aggregate formation in the ER of AVP neurons was further impaired in FNDI/ATF6(-/-) mice compared with that in FNDI mice, and AVP neuronal loss was accelerated in FNDI/ATF6(-/-) mice under WD. These data suggest that ATF6 is required for the AVP neuron system to maintain water balance under dehydration.  (日)    [継承]
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誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 155 [継承]
(必須): 12 [継承]
(必須): 4905 4914 [継承]
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年月日 (必須): 西暦 2014年 9月 9日 (平成 26年 9月 9日) [継承]
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DOI (任意): 10.1210/en.2014-1522    (→Scopusで検索) [継承]
PMID (任意): 25203138    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yoshinori Azuma, Daisuke Hagiwara, Wenjun Lu, Yoshiaki Morishita, Hidetaka Suga, Motomitsu Goto, Ryoichi Banno, Yoshihisa Sugimura, Seiichi Oyadomari, Kazutoshi Mori, Akira Shiota, Naoya Asai, Masahide Takahashi, Yutaka Oiso and Hiroshi Arima : Activating transcription factor 6 is required for the vasopressin neuron system to maintain water balance under dehydration in male mice., Endocrinology, Vol.155, No.12, 4905-4914, 2014.
欧文冊子 ● Yoshinori Azuma, Daisuke Hagiwara, Wenjun Lu, Yoshiaki Morishita, Hidetaka Suga, Motomitsu Goto, Ryoichi Banno, Yoshihisa Sugimura, Seiichi Oyadomari, Kazutoshi Mori, Akira Shiota, Naoya Asai, Masahide Takahashi, Yutaka Oiso and Hiroshi Arima : Activating transcription factor 6 is required for the vasopressin neuron system to maintain water balance under dehydration in male mice., Endocrinology, Vol.155, No.12, 4905-4914, 2014.

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