『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=288081EID:288081, Map:0, LastModified:2014年11月12日(水) 15:21:12, Operator:[松本 高広], Avail:TRUE, Censor:0, Owner:[松本 高広], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Yu Tai-yong (日) (読)
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[継承]
2.近藤 剛史
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[継承]
3.松本 高広 ([徳島大学.大学院医歯薬学研究部.医学域.特定研究部門.研究支援系.動物資源研究]/[徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター.動物資源研究部門])
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学籍番号 (推奨):
[継承]
4. (英) Fujii-Kuriyama Yoshiaki (日) (読)
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[継承]
5. (英) Imai Yuuki (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Aryl hydrocarbon receptor catabolic activity in bone metabolism is osteoclast dependent in vivo.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Bone mass is regulated by various molecules including endogenous factors as well as exogenous factors, such as nutrients and pollutants. Aryl hydrocarbon receptor (AhR) is known as a dioxin receptor and is responsible for various pathological and physiological processes. However, the role of AhR in bone homeostasis remains elusive because the cell type specific direct function of AhR has never been explored in vivo. Here, we show the cell type specific function of AhR in vivo in bone homeostasis. Systemic AhR knockout (AhRKO) mice exhibit increased bone mass with decreased resorption and decreased formation. Meanwhile, osteoclast specific AhRKO (AhR(Oc/Oc)) mice have increased bone mass with reduced bone resorption, although the mice lacking AhR in osteoblasts have a normal bone phenotype. Even under pathological conditions, AhR(Oc/Oc) mice are resistant to sex hormone deficiency-induced bone loss resulting from increased bone resorption. Furthermore, 3-methylcholanthrene, an AhR agonist, induces low bone mass with increased bone resorption in control mice, but not in AhR(Oc/Oc) mice. Taken together, cell type specific in vivo evidence for AhR functions indicates that osteoclastic AhR plays a significant role in maintenance of bone homeostasis, suggesting that inhibition of AhR in osteoclasts can be beneficial in the treatment of osteoporosis.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Bone Density (日) (読) [継承]
3. (英) Bone Resorption (日) (読) [継承]
4. (英) Female (日) (読) [継承]
5. (英) Femur (日) (読) [継承]
6. (英) Male (日) (読) [継承]
7.骨ミネラル代謝 (bone and mineral metabolism) [継承]
8.ノックアウトマウス (knockout mice) [継承]
9. (英) Mice, Knockout (日) (読) [継承]
10. (英) Organ Size (日) (読) [継承]
11. (英) Osteoclasts (日) (読) [継承]
12. (英) Ovariectomy (日) (読) [継承]
13. (英) Receptors, Aryl Hydrocarbon (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)

ISSN (任意): 1090-2104
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem. Biophys. Res. Commun.
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 450 [継承]
(必須): 1 [継承]
(必須): 416 422 [継承]
都市 (任意):
年月日 (必須): 西暦 2014年 6月 2日 (平成 26年 6月 2日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bbrc.2014.05.114    (→Scopusで検索) [継承]
PMID (任意): 24938130    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tai-yong Yu, Takeshi Kondo, Takahiro Matsumoto, Yoshiaki Fujii-Kuriyama and Yuuki Imai : Aryl hydrocarbon receptor catabolic activity in bone metabolism is osteoclast dependent in vivo., Biochemical and Biophysical Research Communications, Vol.450, No.1, 416-422, 2014.
欧文冊子 ● Tai-yong Yu, Takeshi Kondo, Takahiro Matsumoto, Yoshiaki Fujii-Kuriyama and Yuuki Imai : Aryl hydrocarbon receptor catabolic activity in bone metabolism is osteoclast dependent in vivo., Biochemical and Biophysical Research Communications, Vol.450, No.1, 416-422, 2014.

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