| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | (英) Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study Group. (日) (読)
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| ○題名 (必須): | □ | (英) Design and baseline characteristics of a study of primary prevention of coronary events with pravastatin among Japanese with mildly elevated cholesterol levels. (日)
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| ○要約 (任意): | □ | (英) BACKGROUND: Although cholesterol management reportedly reduces fatal and non-fatal coronary heart disease (CHD) events in subjects with or without evident atherosclerotic disease, it is still uncertain whether these benefits extend to Japanese.METHODS AND RESULTS: The study group comprised 8,009 subjects with mildly elevated total cholesterol who were randomized to treatment with 10-20 mg pravastatin plus diet (2,691 women, 1,267 men) or diet alone (2,758 women, 1,293 men). The groups were extremely well balanced with respect to baseline demographics and risk factors such as blood pressure and plasma lipids. Over a 5-year period of follow-up, the primary end-points will be a composite of fatal and non-fatal coronary events. Secondary end-points will include stroke and transient ischemic attack, all cardiovascular events and total mortality.CONCLUSIONS: The 2 groups will be followed up until the end of March 2004 and end-points will be analyzed by full analysis set. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Anticholesteremic Agents (日) (読)
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| 4. | (英) Blood Glucose (日) (読)
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| 5. | (英) Blood Pressure (日) (読)
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| 6. | (英) Body Mass Index (日) (読)
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| 7. | (英) Coronary Disease (日) (読)
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| 8. | (英) Diet (日) (読)
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| 9. | (英) Female (日) (読)
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| 10. | (英) Follow-Up Studies (日) (読)
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| 11. | (英) Humans (日) (読)
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| 12. | (英) Lipids (日) (読)
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| 13. | (英) Male (日) (読)
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| 14. | (英) Middle Aged (日) (読)
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| 15. | (英) Patient Selection (日) (読)
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| 16. | (英) Pravastatin (日) (読)
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| 17. | (英) Primary Prevention (日) (読)
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| 18. | (英) Randomized Controlled Trials as Topic (日) (読)
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| 19. | (英) Retrospective Studies (日) (読)
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| 20. | (英) Time Factors (日) (読)
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| ○発行所 (推奨): | □ | 社団法人 日本循環器学会
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| ○誌名 (必須): | □ | Circulation Journal ([社団法人 日本循環器学会])
(pISSN: 1346-9843, eISSN: 1347-4820)
| ○ISSN (任意): | □ | 1346-9843
ISSN: 1346-9843
(pISSN: 1346-9843, eISSN: 1347-4820) Title: Circulation journal : official journal of the Japanese Circulation SocietyTitle(ISO): Circ JSupplier: 社団法人日本循環器学会Publisher: Japanese Circulation Society (NLM Catalog)
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| ○巻 (必須): | □ | 68
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 860 867
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2004年 8月 25日 (平成 16年 8月 25日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1253/circj.68.860 (→Scopusで検索)
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| ○PMID (任意): | □ | 15329509 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Clinical Trial (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Multicenter Study (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial (日)
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| 5. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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